Entry Database : PDB / ID : 4ncr Structure visualization Downloads & linksTitle Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169 Componentsdecaprenylphosphoryl-beta-D-ribose oxidase Details Keywords OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Decaprenylphosphoryl-beta-D-ribose oxidase / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
arabinan biosynthetic process / cell wall polysaccharide biosynthetic process / decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase / D-arabinono-1,4-lactone oxidase activity / capsule polysaccharide biosynthetic process / FAD binding / cell wall organization / periplasmic space / oxidoreductase activity / response to antibiotic / plasma membrane Similarity search - Function D-arabinono-1,4-lactone oxidase, C-terminal domain / D-arabinono-1,4-lactone oxidase / FAD linked oxidase, N-terminal / FAD binding domain / FAD-binding domain, PCMH-type / PCMH-type FAD-binding domain profile. / FAD-binding, type PCMH, subdomain 2 / FAD-binding, type PCMH-like superfamily Similarity search - Domain/homology Chem-26J / FLAVIN-ADENINE DINUCLEOTIDE / IMIDAZOLE / Decaprenylphosphoryl-beta-D-ribose oxidase / Decaprenylphosphoryl-beta-D-ribose oxidase Similarity search - ComponentBiological species Mycobacterium tuberculosis (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.881 Å DetailsAuthors Neres, J. / Pojer, F. / Cole, S.T. CitationJournal : EMBO Mol Med / Year : 2014Title : Towards a new combination therapy for tuberculosis with next generation benzothiazinones.Authors: Makarov, V. / Lechartier, B. / Zhang, M. / Neres, J. / van der Sar, A.M. / Raadsen, S.A. / Hartkoorn, R.C. / Ryabova, O.B. / Vocat, A. / Decosterd, L.A. / Widmer, N. / Buclin, T. / Bitter, W. ... Authors : Makarov, V. / Lechartier, B. / Zhang, M. / Neres, J. / van der Sar, A.M. / Raadsen, S.A. / Hartkoorn, R.C. / Ryabova, O.B. / Vocat, A. / Decosterd, L.A. / Widmer, N. / Buclin, T. / Bitter, W. / Andries, K. / Pojer, F. / Dyson, P.J. / Cole, S.T. History Deposition Oct 25, 2013 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 19, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Apr 2, 2014 Group : Database referencesRevision 1.2 Sep 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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