登録情報 データベース : PDB / ID : 4my2 構造の表示 ダウンロードとリンクタイトル Crystal Structure of Norrin in fusion with Maltose Binding Protein 要素Maltose-binding periplasmic protein, Norrin fusion protein 詳細 キーワード SIGNALING PROTEIN / Cystine-knot growth factor / Wnt signaling / Cysteine-rich protein / Angiogenesis / Eye development / Wnt/beta-catenin signaling / Frizzled 4 receptor / Lrp5/6 / extracellular / fusion protein機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
retina blood vessel maintenance / cone retinal bipolar cell differentiation / Norrin signaling pathway / extracellular matrix-cell signaling / re-entry into mitotic cell cycle / retinal blood vessel morphogenesis / retinal rod cell differentiation / ubiquitin-dependent endocytosis / glycine metabolic process / retina layer formation ... retina blood vessel maintenance / cone retinal bipolar cell differentiation / Norrin signaling pathway / extracellular matrix-cell signaling / re-entry into mitotic cell cycle / retinal blood vessel morphogenesis / retinal rod cell differentiation / ubiquitin-dependent endocytosis / glycine metabolic process / retina layer formation / retinal pigment epithelium development / endothelial cell differentiation / microglial cell proliferation / dendritic spine development / establishment of blood-retinal barrier / vacuole organization / protein targeting to lysosome / microglia differentiation / establishment of blood-brain barrier / optic nerve development / frizzled binding / retinal ganglion cell axon guidance / lens development in camera-type eye / smoothened signaling pathway / exploration behavior / decidualization / action potential / blood vessel remodeling / carbohydrate transmembrane transporter activity / maltose binding / maltose transport / maltodextrin transmembrane transport / canonical Wnt signaling pathway / response to axon injury / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / tricarboxylic acid cycle / visual perception / glutathione metabolic process / transforming growth factor beta receptor signaling pathway / cytokine activity / nervous system development / mitotic cell cycle / : / outer membrane-bounded periplasmic space / neuron apoptotic process / angiogenesis / cellular response to hypoxia / transcription by RNA polymerase II / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / protein ubiquitination / inflammatory response / positive regulation of DNA-templated transcription / cell surface / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / extracellular space 類似検索 - 分子機能 Norrie disease protein / Glycoprotein hormone subunit beta / Cystine-knot domain / C-terminal cystine knot signature. / C-terminal cystine knot domain profile. / Cystine knot, C-terminal / C-terminal cystine knot-like domain (CTCK) / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / Cystine-knot cytokine ... Norrie disease protein / Glycoprotein hormone subunit beta / Cystine-knot domain / C-terminal cystine knot signature. / C-terminal cystine knot domain profile. / Cystine knot, C-terminal / C-terminal cystine knot-like domain (CTCK) / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / Cystine-knot cytokine / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein / Periplasmic binding protein-like II / D-Maltodextrin-Binding Protein; domain 2 / Ribbon / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性 alpha-maltose / Maltose/maltodextrin-binding periplasmic protein / Norrin 類似検索 - 構成要素生物種 Escherichia coli O157:H7 (大腸菌)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.4 Å 詳細データ登録者 Ke, J. / Jurecky, C. / Chen, C. / Gu, X. / Parker, N. / Williams, B.O. / Melcher, K. / Xu, H.E. 引用ジャーナル : Genes Dev. / 年 : 2013タイトル : Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.著者 : Ke, J. / Harikumar, K.G. / Erice, C. / Chen, C. / Gu, X. / Wang, L. / Parker, N. / Cheng, Z. / Xu, W. / Williams, B.O. / Melcher, K. / Miller, L.J. / Xu, H.E. 履歴 登録 2013年9月27日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2013年11月13日 Provider : repository / タイプ : Initial release改定 1.1 2013年11月20日 Group : Database references改定 1.2 2017年8月9日 Group : Refinement description / Source and taxonomy / カテゴリ : entity_src_gen / software改定 2.0 2020年7月29日 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Non-polymer description / Structure summary カテゴリ : atom_site / chem_comp ... atom_site / chem_comp / entity / entity_name_com / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_molecule_features / pdbx_nonpoly_scheme / pdbx_validate_symm_contact / struct_conn / struct_conn_type / struct_ref_seq_dif / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.type / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_value_order / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry / _struct_ref_seq_dif.details 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 2.1 2023年9月20日 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession改定 2.2 2024年10月30日 Group : Structure summaryカテゴリ : pdbx_entry_details / pdbx_modification_feature
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