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TitleStructure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.
Journal, issue, pagesGenes Dev., Vol. 27, Page 2305-2319, Year 2013
Publish dateSep 27, 2013 (structure data deposition date)
AuthorsKe, J. / Harikumar, K.G. / Erice, C. / Chen, C. / Gu, X. / Wang, L. / Parker, N. / Cheng, Z. / Xu, W. / Williams, B.O. ...Ke, J. / Harikumar, K.G. / Erice, C. / Chen, C. / Gu, X. / Wang, L. / Parker, N. / Cheng, Z. / Xu, W. / Williams, B.O. / Melcher, K. / Miller, L.J. / Xu, H.E.
External linksGenes Dev. / PubMed:24186977
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-4my2:
Crystal Structure of Norrin in fusion with Maltose Binding Protein
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • escherichia coli o157:h7 (bacteria)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Cystine-knot growth factor / Wnt signaling / Cysteine-rich protein / Angiogenesis / Eye development / Wnt/beta-catenin signaling / Frizzled 4 receptor / Lrp5/6 / extracellular / fusion protein

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