登録情報 データベース : PDB / ID : 4mpa 構造の表示 ダウンロードとリンクタイトル Crystal structure of NHERF1-CXCR2 signaling complex in P21 space group 要素Na(+)/H(+) exchange regulatory cofactor NHE-RF1, C-X-C chemokine receptor type 2 chimera 詳細 キーワード STRUCTURAL PROTEIN / neutrophil / inflammatory diseases機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
interleukin-8-mediated signaling pathway / interleukin-8 receptor activity / mast cell granule / import across plasma membrane / regulation of renal phosphate excretion / renal sodium ion transport / type 2 metabotropic glutamate receptor binding / glutathione transport / dopamine receptor binding / renal phosphate ion absorption ... interleukin-8-mediated signaling pathway / interleukin-8 receptor activity / mast cell granule / import across plasma membrane / regulation of renal phosphate excretion / renal sodium ion transport / type 2 metabotropic glutamate receptor binding / glutathione transport / dopamine receptor binding / renal phosphate ion absorption / gamma-aminobutyric acid transmembrane transporter activity / gamma-aminobutyric acid import / cerebrospinal fluid circulation / interleukin-8 binding / negative regulation of sodium ion transport / microvillus assembly / C-X-C chemokine receptor activity / positive regulation of monoatomic ion transmembrane transport / bile acid secretion / maintenance of epithelial cell apical/basal polarity / channel activator activity / stereocilium tip / plasma membrane organization / intracellular phosphate ion homeostasis / cilium organization / gland morphogenesis / myosin II binding / phospholipase C-activating dopamine receptor signaling pathway / C-C chemokine receptor activity / growth factor receptor binding / neutrophil activation / establishment of Golgi localization / C-C chemokine binding / fibroblast migration / type 3 metabotropic glutamate receptor binding / plasma membrane protein complex / establishment of epithelial cell apical/basal polarity / regulation of protein kinase activity / negative regulation of fibroblast migration / chloride channel regulator activity / negative regulation of platelet-derived growth factor receptor signaling pathway / auditory receptor cell stereocilium organization / nuclear migration / Chemokine receptors bind chemokines / dendritic cell chemotaxis / beta-2 adrenergic receptor binding / microvillus membrane / regulation of cell size / renal absorption / microvillus / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of mitotic cell cycle / transport across blood-brain barrier / phosphatase binding / endomembrane system / cellular defense response / positive regulation of intrinsic apoptotic signaling pathway / protein-membrane adaptor activity / sperm midpiece / ruffle / neutrophil chemotaxis / secretory granule membrane / filopodium / protein localization to plasma membrane / cell periphery / morphogenesis of an epithelium / PDZ domain binding / G protein-coupled receptor activity / brush border membrane / sensory perception of sound / calcium-mediated signaling / negative regulation of canonical Wnt signaling pathway / receptor internalization / negative regulation of ERK1 and ERK2 cascade / mitotic spindle / Wnt signaling pathway / beta-catenin binding / adenylate cyclase-activating dopamine receptor signaling pathway / chemotaxis / microtubule cytoskeleton / actin cytoskeleton / phospholipase C-activating G protein-coupled receptor signaling pathway / regulation of cell shape / positive regulation of cytosolic calcium ion concentration / G alpha (i) signalling events / actin cytoskeleton organization / protein-containing complex assembly / vesicle / transmembrane transporter binding / cell surface receptor signaling pathway / inflammatory response / immune response / apical plasma membrane / negative regulation of cell population proliferation / external side of plasma membrane / signaling receptor binding / positive regulation of cell population proliferation / Neutrophil degranulation / protein-containing complex binding / perinuclear region of cytoplasm 類似検索 - 分子機能 CXC chemokine receptor 2 / CXC chemokine receptor 1/2 / EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / : / : / PDZ domain / Pdz3 Domain / PDZ domain ... CXC chemokine receptor 2 / CXC chemokine receptor 1/2 / EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / : / : / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Roll / Mainly Beta 類似検索 - ドメイン・相同性 ACETIC ACID / Na(+)/H(+) exchange regulatory cofactor NHE-RF1 / C-X-C chemokine receptor type 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.097 Å 詳細データ登録者 Jiang, Y. / Lu, G. / Wu, Y. / Brunzelle, J. / Sirinupong, N. / Li, C. / Yang, Z. 引用ジャーナル : Plos One / 年 : 2013タイトル : New Conformational State of NHERF1-CXCR2 Signaling Complex Captured by Crystal Lattice Trapping.著者 : Jiang, Y. / Lu, G. / Trescott, L.R. / Hou, Y. / Guan, X. / Wang, S. / Stamenkovich, A. / Brunzelle, J. / Sirinupong, N. / Li, C. / Yang, Z. 履歴 登録 2013年9月12日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2014年1月15日 Provider : repository / タイプ : Initial release改定 1.1 2017年6月28日 Group : Database references / カテゴリ : struct_ref / struct_ref_seqItem : _struct_ref.pdbx_db_accession / _struct_ref_seq.pdbx_db_accession改定 1.2 2023年9月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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