Entry Database : PDB / ID : 4mhl Structure visualization Downloads & linksTitle The crystal structure of human interleukin-11 ComponentsInterleukin-11 Details Keywords PROTEIN BINDING / Four-helix bundle / Long-chain helical cytokine / Cytokine / Growth factor / Interleukin-11 receptor subunit alpha / Membrane glycoprotein 130 / SecretedFunction / homology Function and homology informationFunction Domain/homology Component
interleukin-11 receptor binding / megakaryocyte differentiation / negative regulation of hormone secretion / interleukin-11-mediated signaling pathway / IL-6-type cytokine receptor ligand interactions / fat cell differentiation / B cell differentiation / cytokine activity / growth factor activity / positive regulation of peptidyl-tyrosine phosphorylation ... interleukin-11 receptor binding / megakaryocyte differentiation / negative regulation of hormone secretion / interleukin-11-mediated signaling pathway / IL-6-type cytokine receptor ligand interactions / fat cell differentiation / B cell differentiation / cytokine activity / growth factor activity / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of peptidyl-serine phosphorylation / cell population proliferation / positive regulation of MAPK cascade / positive regulation of cell population proliferation / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / cytoplasm Similarity search - Function Interleukin-11, mammalian / Interleukin-11 / Interleukin 11 / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.09 Å DetailsAuthors Griffin, M.D.W. CitationJournal : Acta Crystallogr.,Sect.D / Year : 2014Title : The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6.Authors : Putoczki, T.L. / Dobson, R.C. / Griffin, M.D. History Deposition Aug 29, 2013 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Sep 3, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Oct 22, 2014 Group : Database referencesRevision 1.2 Sep 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Show all Show less