Entry | Database: PDB / ID: 4ltb |
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Title | Coiled-coil domain of TRIM25 |
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Components | Tripartite motif-containing 25 variant |
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Keywords | METAL BINDING PROTEIN / Coiled-coil |
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Function / homology | Function and homology information
: / RIG-I binding / regulation of viral entry into host cell / suppression of viral release by host / negative regulation of viral entry into host cell / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / response to vitamin D / TRAF6 mediated IRF7 activation / cytoplasmic pattern recognition receptor signaling pathway / RSV-host interactions ...: / RIG-I binding / regulation of viral entry into host cell / suppression of viral release by host / negative regulation of viral entry into host cell / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / response to vitamin D / TRAF6 mediated IRF7 activation / cytoplasmic pattern recognition receptor signaling pathway / RSV-host interactions / protein monoubiquitination / ligase activity / TRAF6 mediated NF-kB activation / antiviral innate immune response / viral release from host cell / protein K48-linked ubiquitination / ERAD pathway / cellular response to leukemia inhibitory factor / Negative regulators of DDX58/IFIH1 signaling / Termination of translesion DNA synthesis / RING-type E3 ubiquitin transferase / DDX58/IFIH1-mediated induction of interferon-alpha/beta / PKR-mediated signaling / Evasion by RSV of host interferon responses / ISG15 antiviral mechanism / positive regulation of DNA-binding transcription factor activity / cytoplasmic stress granule / response to estrogen / ubiquitin-protein transferase activity / SARS-CoV-1 activates/modulates innate immune responses / regulation of protein localization / Interferon gamma signaling / ubiquitin protein ligase activity / Ovarian tumor domain proteases / positive regulation of NF-kappaB transcription factor activity / TRAF3-dependent IRF activation pathway / ubiquitin-dependent protein catabolic process / positive regulation of canonical NF-kappaB signal transduction / response to oxidative stress / transcription coactivator activity / nuclear body / cadherin binding / innate immune response / SARS-CoV-2 activates/modulates innate and adaptive immune responses / RNA binding / nucleoplasm / metal ion binding / cytoplasm / cytosolSimilarity search - Function TRIM25, PRY/SPRY domain / Zinc finger, RING-type, eukaryotic / RING-type zinc-finger / SPRY-associated domain / SPRY-associated / PRY / Butyrophylin-like, SPRY domain / SPRY domain / B30.2/SPRY domain / B30.2/SPRY domain profile. ...TRIM25, PRY/SPRY domain / Zinc finger, RING-type, eukaryotic / RING-type zinc-finger / SPRY-associated domain / SPRY-associated / PRY / Butyrophylin-like, SPRY domain / SPRY domain / B30.2/SPRY domain / B30.2/SPRY domain profile. / SPRY domain / B30.2/SPRY domain superfamily / Domain in SPla and the RYanodine Receptor. / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Concanavalin A-like lectin/glucanase domain superfamily / Zinc finger, RING/FYVE/PHD-typeSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.59 Å |
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Authors | Pornillos, O. / Sanchez, J.G. / Okreglicka, K. |
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2014 Title: The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer. Authors: Sanchez, J.G. / Okreglicka, K. / Chandrasekaran, V. / Welker, J.M. / Sundquist, W.I. / Pornillos, O. |
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History | Deposition | Jul 23, 2013 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Feb 5, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Mar 19, 2014 | Group: Database references |
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Revision 1.2 | Feb 28, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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