Entry | Database: PDB / ID: 4lnq |
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Title | Crystal structure of Ifi202 HINa domain in complex with 20bp dsDNA |
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Components | - 20bp DNA
- Interferon-activable protein 202
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Keywords | DNA BINDING PROTEIN/DNA / OB fold / DNA binding / DNA BINDING PROTEIN-DNA complex |
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Function / homology | Function and homology information
negative regulation of AIM2 inflammasome complex assembly / cellular response to interferon-beta / activation of innate immune response / negative regulation of innate immune response / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / protein homooligomerization / double-stranded DNA binding / protein homotetramerization / molecular adaptor activity / inflammatory response ...negative regulation of AIM2 inflammasome complex assembly / cellular response to interferon-beta / activation of innate immune response / negative regulation of innate immune response / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / protein homooligomerization / double-stranded DNA binding / protein homotetramerization / molecular adaptor activity / inflammatory response / innate immune response / nucleolus / nucleoplasm / nucleus / cytoplasm / cytosolSimilarity search - Function HIN-200/IF120x / HIN-200 family / HIN-200/IF120x domain / HIN-200 A and B domains profile. / Nucleic acid-binding proteins / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Nucleic acid-binding, OB-fold / Beta Barrel / Mainly BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2 Å |
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Authors | Li, H. / Wang, Z.-X. / Wu, J.-W. |
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Citation | Journal: Acta Crystallogr F Struct Biol Commun / Year: 2014 Title: Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling. Authors: Li, H. / Wang, J. / Wang, J. / Cao, L.S. / Wang, Z.X. / Wu, J.W. |
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History | Deposition | Jul 12, 2013 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jan 8, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Feb 12, 2014 | Group: Database references |
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Revision 1.2 | Sep 20, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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