Entry | Database: PDB / ID: 4lnp |
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Title | The first SH3 domain from CAP/Ponsin in complex with proline rich peptide from Vinculin |
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Components | - Sorbin and SH3 domain-containing protein 1
- Vinculin
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Keywords | SIGNALING PROTEIN / sh3 domain / cell migration / proline rich peptide / focal adhesion |
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Function / homology | Function and homology information
regulation of protein localization to adherens junction / podosome ring / outer dense plaque of desmosome / inner dense plaque of desmosome / terminal web / cell-substrate junction / epithelial cell-cell adhesion / zonula adherens / dystroglycan binding / alpha-catenin binding ...regulation of protein localization to adherens junction / podosome ring / outer dense plaque of desmosome / inner dense plaque of desmosome / terminal web / cell-substrate junction / epithelial cell-cell adhesion / zonula adherens / dystroglycan binding / alpha-catenin binding / flotillin complex / fascia adherens / cell-cell contact zone / adherens junction assembly / apical junction assembly / costamere / regulation of establishment of endothelial barrier / focal adhesion assembly / axon extension / protein localization to cell surface / lamellipodium assembly / regulation of focal adhesion assembly / maintenance of blood-brain barrier / cell-substrate adhesion / stress fiber assembly / brush border / positive regulation of glycogen biosynthetic process / Smooth Muscle Contraction / positive regulation of lipid biosynthetic process / positive regulation of insulin receptor signaling pathway / stress fiber / cytoskeletal protein binding / negative regulation of cell migration / cell-matrix adhesion / cell projection / morphogenesis of an epithelium / positive regulation of glucose import / positive regulation of protein localization to plasma membrane / adherens junction / Signaling by high-kinase activity BRAF mutants / insulin receptor binding / MAP2K and MAPK activation / sarcolemma / beta-catenin binding / nuclear matrix / platelet aggregation / specific granule lumen / cellular response to insulin stimulus / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / Signaling by BRAF and RAF1 fusions / extracellular vesicle / cell-cell junction / Signaling by ALK fusions and activated point mutants / signaling receptor complex adaptor activity / Platelet degranulation / insulin receptor signaling pathway / actin binding / secretory granule lumen / ficolin-1-rich granule lumen / molecular adaptor activity / cytoskeleton / cell adhesion / cadherin binding / membrane raft / focal adhesion / centrosome / ubiquitin protein ligase binding / Neutrophil degranulation / structural molecule activity / protein-containing complex / extracellular exosome / extracellular region / nucleus / plasma membrane / cytoplasm / cytosolSimilarity search - Function c-Cbl associated protein, SH3 domain / c-Cbl associated protein, SH3 domain 1 / c-Cbl associated protein, SH3 domain 2 / SoHo domain / Sorbin homologous domain / SoHo domain profile. / Sorbin homologous domain / Vinculin repeated domain signature. / Vinculin / Vinculin, conserved site ...c-Cbl associated protein, SH3 domain / c-Cbl associated protein, SH3 domain 1 / c-Cbl associated protein, SH3 domain 2 / SoHo domain / Sorbin homologous domain / SoHo domain profile. / Sorbin homologous domain / Vinculin repeated domain signature. / Vinculin / Vinculin, conserved site / Vinculin family talin-binding region signature. / Vinculin/alpha-catenin / Vinculin family / Alpha-catenin/vinculin-like superfamily / Variant SH3 domain / Variant SH3 domain / SH3 Domains / SH3 domain / SH3 type barrels. / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Roll / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.41 Å |
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Authors | Zhao, D. / Li, F. / Wu, J. / Shi, Y. / Zhang, Z. / Gong, Q. |
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Citation | Journal: J.Struct.Biol. / Year: 2014 Title: Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin Authors: Zhao, D. / Wang, X. / Peng, J. / Wang, C. / Li, F. / Sun, Q. / Zhang, Y. / Zhang, J. / Cai, G. / Zuo, X. / Wu, J. / Shi, Y. / Zhang, Z. / Gong, Q. |
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History | Deposition | Jul 11, 2013 | Deposition site: RCSB / Processing site: PDBJ |
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Revision 1.0 | May 28, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jun 4, 2014 | Group: Derived calculations |
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Revision 1.2 | Dec 10, 2014 | Group: Database references |
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Revision 1.3 | Mar 20, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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