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- PDB-1h8c: UBX domain from human faf1 -

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Basic information

Entry
Database: PDB / ID: 1h8c
TitleUBX domain from human faf1
ComponentsFAS-ASSOCIATED FACTOR 1
KeywordsAPOPTOSIS / FAF1 UBX DOMAIN UBIQUITIN-LIKE
Function / homology
Function and homology information


ooplasm / CD95 death-inducing signaling complex / positive regulation of extrinsic apoptotic signaling pathway via death domain receptors / cytoplasmic sequestering of NF-kappaB / protein kinase regulator activity / VCP-NPL4-UFD1 AAA ATPase complex / regulation of protein catabolic process / NF-kappaB binding / regulation of cell adhesion / : ...ooplasm / CD95 death-inducing signaling complex / positive regulation of extrinsic apoptotic signaling pathway via death domain receptors / cytoplasmic sequestering of NF-kappaB / protein kinase regulator activity / VCP-NPL4-UFD1 AAA ATPase complex / regulation of protein catabolic process / NF-kappaB binding / regulation of cell adhesion / : / heat shock protein binding / positive regulation of DNA replication / ubiquitin binding / positive regulation of protein-containing complex assembly / positive regulation of protein catabolic process / nuclear envelope / proteasome-mediated ubiquitin-dependent protein catabolic process / positive regulation of apoptotic process / protein domain specific binding / apoptotic process / ubiquitin protein ligase binding / protein kinase binding / perinuclear region of cytoplasm / endoplasmic reticulum / nucleoplasm / nucleus / cytosol
Similarity search - Function
: / Fas-associated factor 1 / FAS-associated factor 1-like, UBX domain / FAF1, UBA-like domain / UAS / UAS / Domain present in ubiquitin-regulatory proteins / UBX domain / UBX domain / UBX domain profile. ...: / Fas-associated factor 1 / FAS-associated factor 1-like, UBX domain / FAF1, UBA-like domain / UAS / UAS / Domain present in ubiquitin-regulatory proteins / UBX domain / UBX domain / UBX domain profile. / UBA-like domain / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ubiquitin-like (UB roll) / Thioredoxin-like superfamily / Ubiquitin-like domain superfamily / Roll / Alpha Beta
Similarity search - Domain/homology
FAS-associated factor 1
Similarity search - Component
Biological speciesHOMO SAPIENS (human)
MethodSOLUTION NMR
AuthorsBycroft, M.M.
Citation
Journal: J.Mol.Biol. / Year: 2001
Title: The Ubx Domain: A Widespread Ubiquitin-Like Module
Authors: Buchberger, A. / Howard, M.J. / Proctor, M. / Bycroft, M.M.
#1: Journal: Biochem.Biophys.Res.Commun. / Year: 1999
Title: Identification and Characterization of Human Fas Associated Factor 1, Hfaf1
Authors: Ryu, S.W. / Chae, S.K. / Lee, K.J. / Kim, E.
History
DepositionFeb 1, 2001Deposition site: PDBE / Processing site: PDBE
Revision 1.0Feb 13, 2001Provider: repository / Type: Initial release
Revision 1.1May 8, 2011Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: FAS-ASSOCIATED FACTOR 1


Theoretical massNumber of molelcules
Total (without water)9,6001
Polymers9,6001
Non-polymers00
Water0
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)20 / 100LOWEST VIOLATIONS
RepresentativeModel #1

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Components

#1: Protein FAS-ASSOCIATED FACTOR 1 / FAF1


Mass: 9600.015 Da / Num. of mol.: 1 / Fragment: UBX DOMAIN
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) HOMO SAPIENS (human) / Production host: ESCHERICHIA COLI (E. coli) / References: UniProt: Q9UNN5

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Sample conditionspH: 5.8 / Temperature: 310 K
Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

NMR softwareName: X-PLOR / Version: 3.1 / Developer: BRUNGER / Classification: refinement
NMR ensembleConformer selection criteria: LOWEST VIOLATIONS / Conformers calculated total number: 100 / Conformers submitted total number: 20

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