Entry Database : PDB / ID : 4l9m Structure visualization Downloads & linksTitle Autoinhibited state of the Ras-specific exchange factor RasGRP1 ComponentsRAS guanyl-releasing protein 1 Details Keywords SIGNALING PROTEIN / Ras nucleotide exchange factorFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of natural killer cell differentiation / diacylglycerol binding / positive regulation of T cell differentiation in thymus / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / secretory granule localization / Effects of PIP2 hydrolysis / vesicle transport along microtubule / positive regulation of natural killer cell mediated cytotoxicity / phosphatidylcholine binding / natural killer cell activation ... positive regulation of natural killer cell differentiation / diacylglycerol binding / positive regulation of T cell differentiation in thymus / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / secretory granule localization / Effects of PIP2 hydrolysis / vesicle transport along microtubule / positive regulation of natural killer cell mediated cytotoxicity / phosphatidylcholine binding / natural killer cell activation / Rap1 signalling / inflammatory response to antigenic stimulus / positive regulation of Ras protein signal transduction / activation of GTPase activity / positive regulation of granulocyte macrophage colony-stimulating factor production / mast cell degranulation / B cell activation / B cell proliferation / Activation of RAS in B cells / regulation of ERK1 and ERK2 cascade / T cell proliferation / T cell activation / Integrin signaling / positive regulation of MAP kinase activity / positive regulation of GTPase activity / guanyl-nucleotide exchange factor activity / positive regulation of JNK cascade / FCERI mediated NF-kB activation / positive regulation of type II interferon production / positive regulation of tumor necrosis factor production / RAF/MAP kinase cascade / Ras protein signal transduction / positive regulation of ERK1 and ERK2 cascade / cell differentiation / positive regulation of protein phosphorylation / Golgi membrane / lipid binding / calcium ion binding / endoplasmic reticulum membrane / Golgi apparatus / signal transduction / zinc ion binding / identical protein binding / membrane / plasma membrane / cytosol Similarity search - Function Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Son of sevenless (SoS) protein; Chain S, domain 1 / Son of sevenless (SoS) protein Chain: S domain 1 / Son of Sevenless (SoS) protein; Chain S, domain 2 / Ras guanine-nucleotide exchange factors catalytic domain / EF-hand domain / RasGEF N-terminal motif / Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif / Ras-like guanine nucleotide exchange factor, N-terminal / Ras guanine-nucleotide exchange factors N-terminal domain profile. ... Wheat Germ Agglutinin (Isolectin 2); domain 1 - #20 / Son of sevenless (SoS) protein; Chain S, domain 1 / Son of sevenless (SoS) protein Chain: S domain 1 / Son of Sevenless (SoS) protein; Chain S, domain 2 / Ras guanine-nucleotide exchange factors catalytic domain / EF-hand domain / RasGEF N-terminal motif / Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif / Ras-like guanine nucleotide exchange factor, N-terminal / Ras guanine-nucleotide exchange factors N-terminal domain profile. / Ras-like guanine nucleotide exchange factor / Ras guanine-nucleotide exchange factor, catalytic domain superfamily / Ras guanine nucleotide exchange factor domain superfamily / RasGEF domain / Ras guanine-nucleotide exchange factors catalytic domain profile. / Guanine nucleotide exchange factor for Ras-like small GTPases / Ras guanine-nucleotide exchange factors catalytic domain / Diacylglycerol/phorbol-ester binding / Wheat Germ Agglutinin (Isolectin 2); domain 1 / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C1-like domain superfamily / EF-hand / Recoverin; domain 1 / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Up-down Bundle / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3 Å DetailsAuthors Iwig, J.S. / Vercoulen, Y. / Das, R. / Barros, T. / Limnander, A. / Che, Y. / Pelton, J.G. / Wemmer, D.E. / Roose, J.P. / Kuriyan, J. CitationJournal : Elife / Year : 2013Title : Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.Authors : Iwig, J.S. / Vercoulen, Y. / Das, R. / Barros, T. / Limnander, A. / Che, Y. / Pelton, J.G. / Wemmer, D.E. / Roose, J.P. / Kuriyan, J. History Deposition Jun 18, 2013 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 21, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Sep 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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