登録情報 | データベース: PDB / ID: 4kfp |
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タイトル | Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived Ureas as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) |
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要素 | Nicotinamide phosphoribosyltransferase |
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キーワード | Transferase/Transferase Inhibitor / Transferase-Transferase Inhibitor complex |
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機能・相同性 | 機能・相同性情報
nicotinamide phosphoribosyltransferase / nicotinamide phosphoribosyltransferase activity / : / NAD+ biosynthetic process / NPAS4 regulates expression of target genes / BMAL1:CLOCK,NPAS2 activates circadian expression / cytokine activity / circadian regulation of gene expression / cell junction / cell-cell signaling ...nicotinamide phosphoribosyltransferase / nicotinamide phosphoribosyltransferase activity / : / NAD+ biosynthetic process / NPAS4 regulates expression of target genes / BMAL1:CLOCK,NPAS2 activates circadian expression / cytokine activity / circadian regulation of gene expression / cell junction / cell-cell signaling / positive regulation of canonical NF-kappaB signal transduction / positive regulation of ERK1 and ERK2 cascade / nuclear speck / inflammatory response / positive regulation of cell population proliferation / positive regulation of gene expression / signal transduction / positive regulation of transcription by RNA polymerase II / extracellular exosome / identical protein binding / cytosol類似検索 - 分子機能 Nicotinamide phosphoribosyl transferase / Nicotinamide phosphoribosyltransferase, N-terminal domain / Nicotinamide phosphoribosyltransferase, N-terminal domain / Nicotinate/nicotinamide phosphoribosyltransferase / Nicotinate phosphoribosyltransferase (NAPRTase) family / Nicotinate phosphoribosyltransferase-like, C-terminal / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta類似検索 - ドメイン・相同性 Chem-1R7 / PHOSPHATE ION / Nicotinamide phosphoribosyltransferase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.84 Å |
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データ登録者 | Dragovich, P.S. / Bair, K.W. / Baumeister, T. / Ho, Y. / Liederer, B.M. / Liu, X. / O'Brien, T. / Oeh, J. / Sampath, D. / Skelton, N. ...Dragovich, P.S. / Bair, K.W. / Baumeister, T. / Ho, Y. / Liederer, B.M. / Liu, X. / O'Brien, T. / Oeh, J. / Sampath, D. / Skelton, N. / Wang, L. / Wang, W. / Wu, H. / Xiao, Y. / Yuen, P. / Zak, M. / Zhang, L. / Zheng, X. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2013 タイトル: Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). 著者: Dragovich, P.S. / Bair, K.W. / Baumeister, T. / Ho, Y.C. / Liederer, B.M. / Liu, X. / Liu, Y. / O'Brien, T. / Oeh, J. / Sampath, D. / Skelton, N. / Wang, L. / Wang, W. / Wu, H. / Xiao, Y. / ...著者: Dragovich, P.S. / Bair, K.W. / Baumeister, T. / Ho, Y.C. / Liederer, B.M. / Liu, X. / Liu, Y. / O'Brien, T. / Oeh, J. / Sampath, D. / Skelton, N. / Wang, L. / Wang, W. / Wu, H. / Xiao, Y. / Yuen, P.W. / Zak, M. / Zhang, L. / Zheng, X. |
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履歴 | 登録 | 2013年4月27日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年8月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年8月21日 | Group: Database references |
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改定 1.2 | 2024年2月28日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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