登録情報 | データベース: PDB / ID: 4k2o |
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タイトル | The Structure of a Triple Mutant of the Tiam1 PH-CC-Ex Domain |
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要素 | T-lymphoma invasion and metastasis-inducing protein 1 |
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キーワード | SIGNALING PROTEIN / PH and coiled coil domain / phosphoinositide binding / protein-protein interaction / Par-3 / tight junctions |
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機能・相同性 | 機能・相同性情報
positive regulation of Schwann cell chemotaxis / regulation of non-canonical Wnt signaling pathway / regulation of dopaminergic neuron differentiation / extrinsic component of postsynaptic density membrane / Activated NTRK2 signals through CDK5 / regulation of epithelial to mesenchymal transition / regulation of modification of postsynaptic actin cytoskeleton / positive regulation of dendritic spine morphogenesis / regulation of insulin secretion involved in cellular response to glucose stimulus / cell-cell contact zone ...positive regulation of Schwann cell chemotaxis / regulation of non-canonical Wnt signaling pathway / regulation of dopaminergic neuron differentiation / extrinsic component of postsynaptic density membrane / Activated NTRK2 signals through CDK5 / regulation of epithelial to mesenchymal transition / regulation of modification of postsynaptic actin cytoskeleton / positive regulation of dendritic spine morphogenesis / regulation of insulin secretion involved in cellular response to glucose stimulus / cell-cell contact zone / protein localization to membrane / cardiac muscle hypertrophy / activation of GTPase activity / regulation of small GTPase mediated signal transduction / Wnt signaling pathway, planar cell polarity pathway / neuron projection extension / main axon / positive regulation of axonogenesis / small GTPase-mediated signal transduction / NRAGE signals death through JNK / Rac protein signal transduction / CDC42 GTPase cycle / RHOA GTPase cycle / EPH-ephrin mediated repulsion of cells / ephrin receptor signaling pathway / RAC2 GTPase cycle / RAC3 GTPase cycle / axonal growth cone / positive regulation of epithelial to mesenchymal transition / EPHB-mediated forward signaling / RAC1 GTPase cycle / regulation of ERK1 and ERK2 cascade / cell-matrix adhesion / guanyl-nucleotide exchange factor activity / response to cocaine / receptor tyrosine kinase binding / kinase binding / ruffle membrane / G alpha (12/13) signalling events / cell-cell junction / cell migration / positive regulation of protein binding / microtubule binding / protein-containing complex assembly / microtubule / dendritic spine / positive regulation of cell migration / neuronal cell body / lipid binding / glutamatergic synapse / synapse / positive regulation of cell population proliferation / plasma membrane / cytosol類似検索 - 分子機能 Helix Hairpins - #680 / TIAM1, CC-Ex domain / Tiam1/Tiam2/Protein still life / T-lymphoma invasion and metastasis CC-Ex domain / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / Raf-like Ras-binding domain / Raf-like Ras-binding / Ras-binding domain (RBD) profile. / Raf-like Ras-binding domain ...Helix Hairpins - #680 / TIAM1, CC-Ex domain / Tiam1/Tiam2/Protein still life / T-lymphoma invasion and metastasis CC-Ex domain / Guanine-nucleotide dissociation stimulator, CDC24, conserved site / Dbl homology (DH) domain signature. / Raf-like Ras-binding domain / Raf-like Ras-binding / Ras-binding domain (RBD) profile. / Raf-like Ras-binding domain / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / Helix Hairpins / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / PH domain / PH domain profile. / PDZ domain / Pleckstrin homology domain. / Pleckstrin homology domain / PDZ domain profile. / Helix non-globular / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Special / PH-like domain superfamily / Roll / Mainly Beta類似検索 - ドメイン・相同性 Rho guanine nucleotide exchange factor TIAM1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.15 Å |
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データ登録者 | Joshi, M. / Gakhar, L. / Fuentes, E.J. |
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引用 | ジャーナル: Acta Crystallogr.,Sect.F / 年: 2013 タイトル: High-resolution structure of the Tiam1 PHn-CC-Ex domain. 著者: Joshi, M. / Gakhar, L. / Fuentes, E.J. |
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履歴 | 登録 | 2013年4月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年7月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年9月11日 | Group: Database references |
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改定 1.2 | 2023年9月20日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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