登録情報 | データベース: PDB / ID: 4jra |
---|
タイトル | CRYSTAL STRUCTURE OF THE BOTULINUM NEUROTOXIN A RECEPTOR-BINDING DOMAIN IN COMPLEX WITH THE LUMINAL DOMAIN Of SV2C |
---|
要素 | - Botulinum neurotoxin type A
- Synaptic vesicle glycoprotein 2C
|
---|
キーワード | HYDROLASE / Beta-helix / Vesicles / lumen / toxin |
---|
機能・相同性 | 機能・相同性情報
Toxicity of botulinum toxin type F (botF) / host cell junction / Toxicity of botulinum toxin type D (botD) / Toxicity of botulinum toxin type A (botA) / negative regulation of neurotransmitter secretion / bontoxilysin / dopaminergic synapse / host cell presynaptic membrane / host cell cytoplasmic vesicle / host cell cytosol ...Toxicity of botulinum toxin type F (botF) / host cell junction / Toxicity of botulinum toxin type D (botD) / Toxicity of botulinum toxin type A (botA) / negative regulation of neurotransmitter secretion / bontoxilysin / dopaminergic synapse / host cell presynaptic membrane / host cell cytoplasmic vesicle / host cell cytosol / neurotransmitter transport / regulation of synaptic vesicle exocytosis / transmembrane transporter activity / protein transmembrane transporter activity / membrane => GO:0016020 / metalloendopeptidase activity / synaptic vesicle membrane / synaptic vesicle / toxin activity / chemical synaptic transmission / host cell plasma membrane / proteolysis / extracellular region / zinc ion binding / membrane / plasma membrane類似検索 - 分子機能 Pentapeptide repeat region / E3 ubiquitin-protein ligase SopA / : / SV2A/B/C luminal domain / Synaptic vesicle protein SV2 / Sugar transporter, conserved site / Major facilitator, sugar transporter-like / Sugar (and other) transporter / Clostridium neurotoxin, translocation / Clostridium neurotoxin, Translocation domain ...Pentapeptide repeat region / E3 ubiquitin-protein ligase SopA / : / SV2A/B/C luminal domain / Synaptic vesicle protein SV2 / Sugar transporter, conserved site / Major facilitator, sugar transporter-like / Sugar (and other) transporter / Clostridium neurotoxin, translocation / Clostridium neurotoxin, Translocation domain / Clostridium neurotoxin, translocation domain / Clostridial neurotoxin zinc protease / Botulinum/Tetanus toxin, catalytic chain / Clostridium neurotoxin, receptor-binding C-terminal / Clostridium neurotoxin, receptor binding N-terminal / Clostridium neurotoxin, C-terminal receptor binding / Clostridium neurotoxin, N-terminal receptor binding / Pectate Lyase C-like / Kunitz inhibitor STI-like superfamily / Major facilitator superfamily / Major Facilitator Superfamily / Major facilitator superfamily domain / Major facilitator superfamily (MFS) profile. / 3 Solenoid / Trefoil (Acidic Fibroblast Growth Factor, subunit A) - #50 / Trefoil (Acidic Fibroblast Growth Factor, subunit A) / Trefoil / MFS transporter superfamily / Jelly Rolls - #200 / Neutral zinc metallopeptidases, zinc-binding region signature. / Concanavalin A-like lectin/glucanase domain superfamily / Jelly Rolls / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 Botulinum neurotoxin type A / Botulinum neurotoxin type A / Synaptic vesicle glycoprotein 2C類似検索 - 構成要素 |
---|
生物種 |  Clostridium botulinum (ボツリヌス菌)
Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
---|
データ登録者 | Benoit, R.M. / Frey, D. / Wieser, M.M. / Jaussi, R. / Schertler, G.F.X. / Capitani, G. / Kammerer, R.A. |
---|
引用 | ジャーナル: Nature / 年: 2014 タイトル: Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A. 著者: Benoit, R.M. / Frey, D. / Hilbert, M. / Kevenaar, J.T. / Wieser, M.M. / Stirnimann, C.U. / McMillan, D. / Ceska, T. / Lebon, F. / Jaussi, R. / Steinmetz, M.O. / Schertler, G.F. / Hoogenraad, ...著者: Benoit, R.M. / Frey, D. / Hilbert, M. / Kevenaar, J.T. / Wieser, M.M. / Stirnimann, C.U. / McMillan, D. / Ceska, T. / Lebon, F. / Jaussi, R. / Steinmetz, M.O. / Schertler, G.F. / Hoogenraad, C.C. / Capitani, G. / Kammerer, R.A. |
---|
履歴 | 登録 | 2013年3月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2013年11月20日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2013年11月27日 | Group: Database references |
---|
改定 1.2 | 2014年2月12日 | Group: Database references |
---|
改定 1.3 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|