Entry | Database: PDB / ID: 4jnk |
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Title | Lactate Dehydrogenase A in complex with inhibitor compound 22 |
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Components | L-lactate dehydrogenase A chain |
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Keywords | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / alpha-beta / pyruvate reductase and lactate dehydrogenase / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |
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Function / homology | Function and homology information
oxidoreductase complex / L-lactate dehydrogenase / Pyruvate metabolism / lactate metabolic process / L-lactate dehydrogenase activity / pyruvate metabolic process / substantia nigra development / Regulation of pyruvate metabolism / glycolytic process / cadherin binding ...oxidoreductase complex / L-lactate dehydrogenase / Pyruvate metabolism / lactate metabolic process / L-lactate dehydrogenase activity / pyruvate metabolic process / substantia nigra development / Regulation of pyruvate metabolism / glycolytic process / cadherin binding / mitochondrion / extracellular exosome / identical protein binding / membrane / nucleus / cytosolSimilarity search - Function L-lactate dehydrogenase / L-lactate dehydrogenase active site. / L-lactate dehydrogenase, active site / L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 / Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal / L-lactate/malate dehydrogenase / Lactate/malate dehydrogenase, N-terminal / Lactate/malate dehydrogenase, C-terminal / lactate/malate dehydrogenase, NAD binding domain / lactate/malate dehydrogenase, alpha/beta C-terminal domain ...L-lactate dehydrogenase / L-lactate dehydrogenase active site. / L-lactate dehydrogenase, active site / L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2 / Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal / L-lactate/malate dehydrogenase / Lactate/malate dehydrogenase, N-terminal / Lactate/malate dehydrogenase, C-terminal / lactate/malate dehydrogenase, NAD binding domain / lactate/malate dehydrogenase, alpha/beta C-terminal domain / Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Alpha-Beta Complex / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.896 Å |
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Authors | Eigenbrot, C. / Ultsch, M. |
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Citation | Journal: Bioorg.Med.Chem.Lett. / Year: 2013 Title: Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase. Authors: Dragovich, P.S. / Fauber, B.P. / Corson, L.B. / Ding, C.Z. / Eigenbrot, C. / Ge, H. / Giannetti, A.M. / Hunsaker, T. / Labadie, S. / Liu, Y. / Malek, S. / Pan, B. / Peterson, D. / Pitts, K. ...Authors: Dragovich, P.S. / Fauber, B.P. / Corson, L.B. / Ding, C.Z. / Eigenbrot, C. / Ge, H. / Giannetti, A.M. / Hunsaker, T. / Labadie, S. / Liu, Y. / Malek, S. / Pan, B. / Peterson, D. / Pitts, K. / Purkey, H.E. / Sideris, S. / Ultsch, M. / Vanderporten, E. / Wei, B. / Xu, Q. / Yen, I. / Yue, Q. / Zhang, H. / Zhang, X. |
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History | Deposition | Mar 15, 2013 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | May 22, 2013 | Provider: repository / Type: Initial release |
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Revision 1.1 | Sep 20, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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Revision 2.0 | Nov 15, 2023 | Group: Atomic model / Data collection / Category: atom_site / chem_comp_atom / chem_comp_bond Item: _atom_site.auth_atom_id / _atom_site.label_atom_id ..._atom_site.auth_atom_id / _atom_site.label_atom_id / _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_1 / _chem_comp_bond.atom_id_2 |
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