登録情報 | データベース: PDB / ID: 4jl7 |
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タイトル | Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1 |
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要素 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 |
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キーワード | SIGNALING PROTEIN / CXCR2 / NHERF1 / Neutrophil / Inflammatory diseases |
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機能・相同性 | 機能・相同性情報
regulation of renal phosphate excretion / renal sodium ion transport / type 2 metabotropic glutamate receptor binding / glutathione transport / dopamine receptor binding / renal phosphate ion absorption / import across plasma membrane / gamma-aminobutyric acid transmembrane transporter activity / gamma-aminobutyric acid import / cerebrospinal fluid circulation ...regulation of renal phosphate excretion / renal sodium ion transport / type 2 metabotropic glutamate receptor binding / glutathione transport / dopamine receptor binding / renal phosphate ion absorption / import across plasma membrane / gamma-aminobutyric acid transmembrane transporter activity / gamma-aminobutyric acid import / cerebrospinal fluid circulation / negative regulation of sodium ion transport / microvillus assembly / maintenance of epithelial cell apical/basal polarity / bile acid secretion / positive regulation of monoatomic ion transmembrane transport / regulation of protein kinase activity / stereocilium tip / channel activator activity / phospholipase C-activating dopamine receptor signaling pathway / plasma membrane organization / cilium organization / gland morphogenesis / growth factor receptor binding / myosin II binding / establishment of Golgi localization / intracellular phosphate ion homeostasis / fibroblast migration / plasma membrane protein complex / establishment of epithelial cell apical/basal polarity / type 3 metabotropic glutamate receptor binding / negative regulation of fibroblast migration / auditory receptor cell stereocilium organization / chloride channel regulator activity / negative regulation of platelet-derived growth factor receptor signaling pathway / beta-2 adrenergic receptor binding / nuclear migration / microvillus membrane / regulation of cell size / renal absorption / microvillus / negative regulation of mitotic cell cycle / phosphatase binding / transport across blood-brain barrier / positive regulation of intrinsic apoptotic signaling pathway / protein-membrane adaptor activity / ruffle / sperm midpiece / endomembrane system / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / protein localization to plasma membrane / cell periphery / morphogenesis of an epithelium / PDZ domain binding / filopodium / sensory perception of sound / negative regulation of canonical Wnt signaling pathway / brush border membrane / negative regulation of ERK1 and ERK2 cascade / beta-catenin binding / Wnt signaling pathway / adenylate cyclase-activating dopamine receptor signaling pathway / actin cytoskeleton / regulation of cell shape / actin cytoskeleton organization / protein-containing complex assembly / vesicle / transmembrane transporter binding / apical plasma membrane / signaling receptor binding / negative regulation of cell population proliferation / protein-containing complex binding / perinuclear region of cytoplasm / extracellular exosome / identical protein binding / membrane / cytoplasm類似検索 - 分子機能 EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / : / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain ...EBP50, C-terminal / Na(+)/H(+) exchange regulatory cofactor NHERF-1/2 / EBP50, C-terminal / : / PDZ domain / Pdz3 Domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Roll / Mainly Beta類似検索 - ドメイン・相同性 Na(+)/H(+) exchange regulatory cofactor NHE-RF1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.16 Å |
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データ登録者 | Lu, G. / Wu, Y. / Jiang, Y. / Brunzelle, J. / Sirinupong, N. / Li, C. / Yang, Z. |
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引用 | ジャーナル: Plos One / 年: 2013 タイトル: Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1. 著者: Lu, G. / Wu, Y. / Jiang, Y. / Wang, S. / Hou, Y. / Guan, X. / Brunzelle, J. / Sirinupong, N. / Sheng, S. / Li, C. / Yang, Z. |
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履歴 | 登録 | 2013年3月12日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年10月23日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年2月28日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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