登録情報 | データベース: PDB / ID: 4jgh |
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タイトル | Structure of the SOCS2-Elongin BC complex bound to an N-terminal fragment of Cullin5 |
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要素 | - Cullin-5
- Suppressor of cytokine signaling 2
- Transcription elongation factor B polypeptide 1
- Transcription elongation factor B polypeptide 2
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キーワード | LIGASE / Cullin-RING E3 ubiquitin ligases / Ubiquitination / Cytosol |
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機能・相同性 | 機能・相同性情報
TP53 Regulates Transcription of DNA Repair Genes / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / RNA Polymerase II Pre-transcription Events / JAK pathway signal transduction adaptor activity / Inactivation of CSF3 (G-CSF) signaling / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / ERBB2 signaling pathway / Neddylation / negative regulation of receptor signaling pathway via JAK-STAT ...TP53 Regulates Transcription of DNA Repair Genes / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / RNA Polymerase II Pre-transcription Events / JAK pathway signal transduction adaptor activity / Inactivation of CSF3 (G-CSF) signaling / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / ERBB2 signaling pathway / Neddylation / negative regulation of receptor signaling pathway via JAK-STAT / Antigen processing: Ubiquitination & Proteasome degradation / 1-phosphatidylinositol-3-kinase regulator activity / target-directed miRNA degradation / elongin complex / VCB complex / phosphatidylinositol 3-kinase complex / growth hormone receptor binding / Cul5-RING ubiquitin ligase complex / growth hormone receptor signaling pathway / SCF ubiquitin ligase complex / Cul2-RING ubiquitin ligase complex / negative regulation of multicellular organism growth / SCF-dependent proteasomal ubiquitin-dependent protein catabolic process / site of DNA damage / cell surface receptor signaling pathway via JAK-STAT / phosphatidylinositol phosphate biosynthetic process / regulation of signal transduction / mammary gland alveolus development / Growth hormone receptor signaling / cellular response to hormone stimulus / insulin-like growth factor receptor binding / Negative regulation of FLT3 / positive regulation of neuron differentiation / lactation / Interleukin-7 signaling / intrinsic apoptotic signaling pathway / transcription corepressor binding / regulation of cell growth / transcription initiation at RNA polymerase II promoter / transcription elongation by RNA polymerase II / Vif-mediated degradation of APOBEC3G / calcium channel activity / Inactivation of CSF3 (G-CSF) signaling / Evasion by RSV of host interferon responses / Downregulation of ERBB2 signaling / G1/S transition of mitotic cell cycle / ubiquitin-protein transferase activity / Antigen processing: Ubiquitination & Proteasome degradation / response to estradiol / signaling receptor activity / Neddylation / protein-macromolecule adaptor activity / ubiquitin-dependent protein catabolic process / transcription regulator complex / transcription coactivator activity / intracellular signal transduction / protein ubiquitination / ubiquitin protein ligase binding / protein-containing complex binding / negative regulation of apoptotic process / nucleus / cytosol / cytoplasm類似検索 - 分子機能 SOCS box / Suppressor of cytokine signalling 2 / SOCS2, SH2 domain / Cullin Repeats / suppressors of cytokine signalling / 5 helical Cullin repeat like / SOCS box / SOCS box-like domain superfamily / SOCS box domain / SOCS box domain profile. ...SOCS box / Suppressor of cytokine signalling 2 / SOCS2, SH2 domain / Cullin Repeats / suppressors of cytokine signalling / 5 helical Cullin repeat like / SOCS box / SOCS box-like domain superfamily / SOCS box domain / SOCS box domain profile. / SOCS_box / Elongin C; Chain C, domain 1 / Cullin protein neddylation domain / Cullin, conserved site / Cullin family signature. / Elongin B / Cullin / Elongin-C / Cullin repeat-like-containing domain superfamily / Cullin protein, neddylation domain / Cullin protein neddylation domain / Potassium Channel Kv1.1; Chain A / Potassium Channel Kv1.1; Chain A / Cullin / Cullin, N-terminal / Cullin homology domain / Cullin homology domain superfamily / Cullin family / Cullin family profile. / S-phase kinase-associated protein 1-like / SKP1 component, POZ domain / Skp1 family, tetramerisation domain / Found in Skp1 protein family / SH2 domain / SHC Adaptor Protein / SKP1/BTB/POZ domain superfamily / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Ubiquitin-like (UB roll) / SH2 domain superfamily / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Ubiquitin-like domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Roll / Up-down Bundle / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Suppressor of cytokine signaling 2 / Elongin-B / Elongin-C / Cullin-5類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3 Å |
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データ登録者 | Kim, Y.K. / Kwak, M.J. / Ku, B. / Suh, H.Y. / Joo, K. / Lee, J. / Jung, J.U. / Oh, B.H. |
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引用 | ジャーナル: Acta Crystallogr.,Sect.D / 年: 2013 タイトル: Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes. 著者: Kim, Y.K. / Kwak, M.J. / Ku, B. / Suh, H.Y. / Joo, K. / Lee, J. / Jung, J.U. / Oh, B.H. |
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履歴 | 登録 | 2013年3月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年8月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年9月20日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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