- PDB-4ip9: Structure of native human serum amyloid A1 -
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Open data
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Basic information
Entry
Database: PDB / ID: 4ip9
Title
Structure of native human serum amyloid A1
Components
Serum amyloid A-1 protein
Keywords
PROTEIN BINDING / double layer hexameric structure / secondary amyloid / High density lipoprotein / human serum
Function / homology
Function and homology information
Scavenging by Class B Receptors / lymphocyte chemotaxis / positive regulation of interleukin-1 production / high-density lipoprotein particle / Formyl peptide receptors bind formyl peptides and many other ligands / macrophage chemotaxis / regulation of protein secretion / cytoplasmic microtubule / TRAF6 mediated NF-kB activation / Advanced glycosylation endproduct receptor signaling ...Scavenging by Class B Receptors / lymphocyte chemotaxis / positive regulation of interleukin-1 production / high-density lipoprotein particle / Formyl peptide receptors bind formyl peptides and many other ligands / macrophage chemotaxis / regulation of protein secretion / cytoplasmic microtubule / TRAF6 mediated NF-kB activation / Advanced glycosylation endproduct receptor signaling / positive regulation of cell adhesion / endocytic vesicle lumen / neutrophil chemotaxis / positive regulation of cytokine production / acute-phase response / G protein-coupled receptor binding / TAK1-dependent IKK and NF-kappa-B activation / platelet activation / negative regulation of inflammatory response / heparin binding / positive regulation of cytosolic calcium ion concentration / G alpha (i) signalling events / G alpha (q) signalling events / Interleukin-4 and Interleukin-13 signaling / Amyloid fiber formation / extracellular exosome / extracellular region Similarity search - Function
Serum amyloid A protein / Serum amyloid A protein / Serum amyloid A protein / Serum amyloid A proteins signature. / Serum amyloid A proteins / Topoisomerase I; Chain A, domain 4 / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
SerumamyloidA-1protein / SAA / Amyloid protein A / Amyloid fibril protein AA / Serum amyloid protein A(2-104) / Serum ...SAA / Amyloid protein A / Amyloid fibril protein AA / Serum amyloid protein A(2-104) / Serum amyloid protein A(3-104) / Serum amyloid protein A(2-103) / Serum amyloid protein A(2-102) / Serum amyloid protein A(4-101)
Mass: 12659.771 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: SAA1 / Production host: Escherichia coli (E. coli) / References: UniProt: P0DJI8
Mass: 18.015 Da / Num. of mol.: 6 / Source method: isolated from a natural source / Formula: H2O
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION
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Sample preparation
Crystal
Density Matthews: 2.18 Å3/Da / Density % sol: 43.69 %
Crystal grow
Temperature: 295 K / Method: vapor diffusion, hanging drop / pH: 8.5 Details: 30% PEG2000 MME, 0.1M Tris (pH8.5) and 0.2 M Trimethylamine N-oxide, VAPOR DIFFUSION, HANGING DROP, temperature 295K
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Data collection
Diffraction
Mean temperature: 100 K
Diffraction source
Source: SYNCHROTRON / Site: APS / Beamline: 22-ID
Detector
Type: MAR CCD 165 mm / Detector: CCD / Date: Jul 4, 2010
Radiation
Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
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