Entry Database : PDB / ID : 4igg Structure visualization Downloads & linksTitle Full-length human alpha-catenin crystal structure ComponentsCatenin alpha-1 Details Keywords CELL ADHESION / Asymmetric dimer / adherens junctions / F-actin bindingFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of integrin-mediated signaling pathway / CDH11 homotypic and heterotypic interactions / Regulation of CDH19 Expression and Function / Regulation of CDH11 function / gamma-catenin binding / epithelial cell-cell adhesion / zonula adherens / gap junction assembly / cellular response to indole-3-methanol / vinculin binding ... negative regulation of integrin-mediated signaling pathway / CDH11 homotypic and heterotypic interactions / Regulation of CDH19 Expression and Function / Regulation of CDH11 function / gamma-catenin binding / epithelial cell-cell adhesion / zonula adherens / gap junction assembly / cellular response to indole-3-methanol / vinculin binding / flotillin complex / negative regulation of cell motility / apical junction assembly / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / catenin complex / positive regulation of smoothened signaling pathway / Adherens junctions interactions / negative regulation of protein localization to nucleus / axon regeneration / negative regulation of neuroblast proliferation / establishment or maintenance of cell polarity / smoothened signaling pathway / Myogenesis / odontogenesis of dentin-containing tooth / intercalated disc / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / neuroblast proliferation / RHO GTPases activate IQGAPs / ovarian follicle development / extrinsic apoptotic signaling pathway in absence of ligand / acrosomal vesicle / VEGFR2 mediated vascular permeability / integrin-mediated signaling pathway / adherens junction / cell-cell adhesion / beta-catenin binding / response to estrogen / male gonad development / actin filament binding / cell-cell junction / protein localization / actin cytoskeleton / cell migration / cell junction / lamellipodium / cell adhesion / cadherin binding / intracellular membrane-bounded organelle / focal adhesion / structural molecule activity / RNA binding / identical protein binding / nucleus / plasma membrane / cytosol Similarity search - Function HR1 repeat / Alpha-catenin / Alpha-catenin/vinculin-like / Vinculin, conserved site / Vinculin family talin-binding region signature. / Vinculin/alpha-catenin / Vinculin family / Alpha-catenin/vinculin-like superfamily / Four Helix Bundle (Hemerythrin (Met), subunit A) / Helix Hairpins ... HR1 repeat / Alpha-catenin / Alpha-catenin/vinculin-like / Vinculin, conserved site / Vinculin family talin-binding region signature. / Vinculin/alpha-catenin / Vinculin family / Alpha-catenin/vinculin-like superfamily / Four Helix Bundle (Hemerythrin (Met), subunit A) / Helix Hairpins / Up-down Bundle / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / SIRAS / Resolution : 3.66 Å DetailsAuthors Izard, T. / Rangarajan, E.S. CitationJournal : Nat.Struct.Mol.Biol. / Year : 2013Title : Dimer asymmetry defines alpha-catenin interactions.Authors : Rangarajan, E.S. / Izard, T. History Deposition Dec 17, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 26, 2012 Provider : repository / Type : Initial releaseRevision 1.1 Sep 11, 2013 Group : Database referencesRevision 1.2 Feb 28, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Show all Show less