登録情報 データベース : PDB / ID : 4i3l 構造の表示 ダウンロードとリンクタイトル Crystal structure of a metabolic reductase with 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one 要素Isocitrate dehydrogenase [NADP] cytoplasmic 詳細 キーワード oxidoreductase/oxidoreductase inhibitor / isocitrate dehydrogenase / oxidoreductase-oxidoreductase inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate / NADPH regeneration / regulation of phospholipid catabolic process / regulation of phospholipid biosynthetic process / NFE2L2 regulating TCA cycle genes / isocitrate metabolic process / isocitrate dehydrogenase (NADP+) / isocitrate dehydrogenase (NADP+) activity / female gonad development / NADPH regeneration ... Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate / NADPH regeneration / regulation of phospholipid catabolic process / regulation of phospholipid biosynthetic process / NFE2L2 regulating TCA cycle genes / isocitrate metabolic process / isocitrate dehydrogenase (NADP+) / isocitrate dehydrogenase (NADP+) activity / female gonad development / NADPH regeneration / NADP+ metabolic process / 2-oxoglutarate metabolic process / glyoxylate cycle / response to steroid hormone / peroxisomal matrix / tricarboxylic acid cycle / glutathione metabolic process / Peroxisomal protein import / NAD binding / peroxisome / tertiary granule lumen / NADP binding / response to oxidative stress / secretory granule lumen / ficolin-1-rich granule lumen / cadherin binding / Neutrophil degranulation / magnesium ion binding / protein homodimerization activity / mitochondrion / extracellular exosome / extracellular region / identical protein binding / cytosol / cytoplasm 類似検索 - 分子機能 Isocitrate dehydrogenase NADP-dependent / Isopropylmalate Dehydrogenase / Isopropylmalate Dehydrogenase / Isocitrate/isopropylmalate dehydrogenase, conserved site / Isocitrate and isopropylmalate dehydrogenases signature. / Isopropylmalate dehydrogenase-like domain / Isocitrate/isopropylmalate dehydrogenase / Isocitrate/isopropylmalate dehydrogenase / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one / Chem-NDP / Isocitrate dehydrogenase [NADP] cytoplasmic 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 3.292 Å 詳細データ登録者 Zheng, B. / Yao, Y. / Liu, Z. / Deng, L. / Anglin, J.L. / Jiang, H. / Prasad, B.V.V. / Song, Y. 引用ジャーナル : ACS Med Chem Lett / 年 : 2013タイトル : Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.著者 : Zheng, B. / Yao, Y. / Liu, Z. / Deng, L. / Anglin, J.L. / Jiang, H. / Prasad, B.V. / Song, Y. 履歴 登録 2012年11月26日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2013年5月22日 Provider : repository / タイプ : Initial release改定 1.1 2013年7月10日 Group : Database references改定 1.2 2024年2月28日 Group : Data collection / Database references / Derived calculationsカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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