登録情報 | データベース: PDB / ID: 4i11 |
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タイトル | Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. |
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要素 | Beta-secretase 1 |
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キーワード | transferase/transferase inhibitor / BACE-1 / transferase-transferase inhibitor complex |
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機能・相同性 | 機能・相同性情報
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ...memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 1.89 Å |
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データ登録者 | Bowers, B. / Xu, Y. / Yuan, S. / Probst, G.D. / Hom, R.K. / Chan, W. / Konradi, A.W. / Sham, H.L. / Zhu, Y.L. / Beroza, P. ...Bowers, B. / Xu, Y. / Yuan, S. / Probst, G.D. / Hom, R.K. / Chan, W. / Konradi, A.W. / Sham, H.L. / Zhu, Y.L. / Beroza, P. / Pan, H. / Brecht, E. / Yao, N. / Lougheed, J. / Artis, D.R. / Tam, D. / Bova, M. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2013 タイトル: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. 著者: Bowers, S. / Xu, Y.Z. / Yuan, S. / Probst, G.D. / Hom, R.K. / Chan, W. / Konradi, A.W. / Sham, H.L. / Zhu, Y.L. / Beroza, P. / Pan, H. / Brecht, E. / Yao, N. / Lougheed, J. / Tam, D. / Ren, Z. ...著者: Bowers, S. / Xu, Y.Z. / Yuan, S. / Probst, G.D. / Hom, R.K. / Chan, W. / Konradi, A.W. / Sham, H.L. / Zhu, Y.L. / Beroza, P. / Pan, H. / Brecht, E. / Yao, N. / Lougheed, J. / Tam, D. / Ren, Z. / Ruslim, L. / Bova, M.P. / Artis, D.R. |
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履歴 | 登録 | 2012年11月19日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年3月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年4月24日 | Group: Database references |
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