登録情報 | データベース: PDB / ID: 4hra |
---|
タイトル | Crystal Structure of DOT1L in Complex with EPZ-5676 |
---|
要素 | Histone-lysine N-methyltransferase, H3 lysine-79 specific |
---|
キーワード | Transferase/Transferase Inhibitor / Histone Lysine Methyltransferase / Transferase / Transferase-Transferase Inhibitor complex |
---|
機能・相同性 | 機能・相同性情報
histone H3K79 trimethyltransferase activity / [histone H3]-lysine79 N-trimethyltransferase / histone H3K79 methyltransferase activity / regulation of transcription regulatory region DNA binding / histone H3 methyltransferase activity / regulation of receptor signaling pathway via JAK-STAT / histone methyltransferase activity / heterochromatin formation / telomere organization / DNA damage checkpoint signaling ...histone H3K79 trimethyltransferase activity / [histone H3]-lysine79 N-trimethyltransferase / histone H3K79 methyltransferase activity / regulation of transcription regulatory region DNA binding / histone H3 methyltransferase activity / regulation of receptor signaling pathway via JAK-STAT / histone methyltransferase activity / heterochromatin formation / telomere organization / DNA damage checkpoint signaling / PKMTs methylate histone lysines / gene expression / methylation / RNA polymerase II-specific DNA-binding transcription factor binding / nucleic acid binding / transcription coactivator activity / intracellular membrane-bounded organelle / DNA repair / positive regulation of cell population proliferation / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 434 Repressor (Amino-terminal Domain) - #60 / Histone H3-K79 methyltransferase, metazoa / Histone-lysine N-methyltransferase DOT1 domain / Histone H3-K79 methyltransferase / Histone methylation protein DOT1 / Histone-lysine N-methyltransferase DOT1 (EC 2.1.1.43) domain profile. / 434 Repressor (Amino-terminal Domain) / Vaccinia Virus protein VP39 / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold ...434 Repressor (Amino-terminal Domain) - #60 / Histone H3-K79 methyltransferase, metazoa / Histone-lysine N-methyltransferase DOT1 domain / Histone H3-K79 methyltransferase / Histone methylation protein DOT1 / Histone-lysine N-methyltransferase DOT1 (EC 2.1.1.43) domain profile. / 434 Repressor (Amino-terminal Domain) / Vaccinia Virus protein VP39 / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-EP6 / Histone-lysine N-methyltransferase, H3 lysine-79 specific類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.15 Å |
---|
データ登録者 | Jin, L. |
---|
引用 | ジャーナル: Blood / 年: 2013 タイトル: Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. 著者: Daigle, S.R. / Olhava, E.J. / Therkelsen, C.A. / Basavapathruni, A. / Jin, L. / Boriack-Sjodin, P.A. / Allain, C.J. / Klaus, C.R. / Raimondi, A. / Scott, M.P. / Waters, N.J. / Chesworth, R. / ...著者: Daigle, S.R. / Olhava, E.J. / Therkelsen, C.A. / Basavapathruni, A. / Jin, L. / Boriack-Sjodin, P.A. / Allain, C.J. / Klaus, C.R. / Raimondi, A. / Scott, M.P. / Waters, N.J. / Chesworth, R. / Moyer, M.P. / Copeland, R.A. / Richon, V.M. / Pollock, R.M. |
---|
履歴 | 登録 | 2012年10月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2013年7月31日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2013年9月4日 | Group: Database references |
---|
改定 1.2 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|