登録情報 | データベース: PDB / ID: 4h3b |
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タイトル | Crystal Structure of JNK3 in Complex with SAB Peptide |
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要素 | - Mitogen-activated protein kinase 10
- SH3 domain-binding protein 5
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キーワード | TRANSFERASE / SH3BP-5 / MAPK / kinase |
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機能・相同性 | 機能・相同性情報
JUN kinase activity / protein kinase inhibitor activity / Activation of the AP-1 family of transcription factors / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / response to light stimulus / mitogen-activated protein kinase / JNK cascade / guanyl-nucleotide exchange factor activity / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 ...JUN kinase activity / protein kinase inhibitor activity / Activation of the AP-1 family of transcription factors / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / response to light stimulus / mitogen-activated protein kinase / JNK cascade / guanyl-nucleotide exchange factor activity / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / FCERI mediated MAPK activation / cytoplasmic vesicle membrane / regulation of circadian rhythm / SH3 domain binding / cellular senescence / rhythmic process / Oxidative Stress Induced Senescence / nuclear body / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / signal transduction / mitochondrion / nucleoplasm / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 SH3-binding 5 / SH3 domain-binding protein 5 (SH3BP5) / Mitogen-activated protein (MAP) kinase, JNK / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site ...SH3-binding 5 / SH3 domain-binding protein 5 (SH3BP5) / Mitogen-activated protein (MAP) kinase, JNK / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 SH3 domain-binding protein 5 / Mitogen-activated protein kinase 10類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.08 Å |
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データ登録者 | Nwachukwu, J.C. / Laughlin, J.D. / Figuera-Losada, M. / Cherry, L. / Nettles, K.W. / LoGrasso, P.V. |
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引用 | ジャーナル: Structure / 年: 2012 タイトル: Structural Mechanisms of Allostery and Autoinhibition in JNK Family Kinases. 著者: Laughlin, J.D. / Nwachukwu, J.C. / Figuera-Losada, M. / Cherry, L. / Nettles, K.W. / Lograsso, P.V. |
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履歴 | 登録 | 2012年9月13日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年11月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年11月28日 | Group: Database references |
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改定 1.2 | 2012年12月26日 | Group: Database references |
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改定 1.3 | 2015年6月17日 | Group: Structure summary |
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改定 1.4 | 2023年9月20日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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