登録情報 | データベース: PDB / ID: 4ffw |
---|
タイトル | Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin |
---|
要素 | - Dipeptidyl peptidase 4
- Fab heavy chain
- Fab light chain
|
---|
キーワード | HYDROLASE/Immune System / INHIBITOR / hydrolase / HYDROLASE-Immune System / INHIBITOR complex |
---|
機能・相同性 | 機能・相同性情報
B-1a B cell differentiation / regulation of T cell mediated immunity / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / positive regulation of natural killer cell mediated immunity / negative regulation of neutrophil chemotaxis / regulation of cell-cell adhesion mediated by integrin / negative regulation of extracellular matrix disassembly / psychomotor behavior / dipeptidyl-peptidase IV ...B-1a B cell differentiation / regulation of T cell mediated immunity / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) / positive regulation of natural killer cell mediated immunity / negative regulation of neutrophil chemotaxis / regulation of cell-cell adhesion mediated by integrin / negative regulation of extracellular matrix disassembly / psychomotor behavior / dipeptidyl-peptidase IV / intercellular canaliculus / chemorepellent activity / dipeptidyl-peptidase activity / locomotory exploration behavior / lamellipodium membrane / endocytic vesicle / endothelial cell migration / behavioral fear response / aminopeptidase activity / collagen binding / T cell costimulation / T cell activation / serine-type peptidase activity / peptide binding / protein catabolic process / lamellipodium / virus receptor activity / protease binding / response to hypoxia / cell adhesion / apical plasma membrane / membrane raft / serine-type endopeptidase activity / signaling receptor binding / positive regulation of cell population proliferation / cell surface / protein homodimerization activity / proteolysis / extracellular region / identical protein binding / plasma membrane類似検索 - 分子機能 Dipeptidyl peptidase 4, low complexity region / Dipeptidyl peptidase IV (DPP IV) low complexity region / Dipeptidylpeptidase IV, N-terminal domain / : / 8 Propeller / Methanol Dehydrogenase; Chain A / Prolyl endopeptidase family serine active site. / Peptidase S9, serine active site / Dipeptidylpeptidase IV, N-terminal domain / Dipeptidyl peptidase IV (DPP IV) N-terminal region ...Dipeptidyl peptidase 4, low complexity region / Dipeptidyl peptidase IV (DPP IV) low complexity region / Dipeptidylpeptidase IV, N-terminal domain / : / 8 Propeller / Methanol Dehydrogenase; Chain A / Prolyl endopeptidase family serine active site. / Peptidase S9, serine active site / Dipeptidylpeptidase IV, N-terminal domain / Dipeptidyl peptidase IV (DPP IV) N-terminal region / Peptidase S9, prolyl oligopeptidase, catalytic domain / Prolyl oligopeptidase family / Alpha/Beta hydrolase fold, catalytic domain / Alpha/Beta hydrolase fold / Immunoglobulins / Immunoglobulin-like / Sandwich / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 |
---|
生物種 | ![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ)
![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.9 Å |
---|
データ登録者 | Wang, Z. / Sudom, A. / Walker, N.P. / Min, X. |
---|
引用 | ジャーナル: To be published タイトル: An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition 著者: Tang, J. / Majeti, J. / Sudom, A. / Xiong, Y. / Lu, M. / Liu, Q. / Higbee, J. / Zhang, Y. / Wang, Y. / Wang, W. / Cao, P. / Xia, Z. / Johnstone, S. / Yang, X. / Yu, T. / Sharkov, N. / Walker, ...著者: Tang, J. / Majeti, J. / Sudom, A. / Xiong, Y. / Lu, M. / Liu, Q. / Higbee, J. / Zhang, Y. / Wang, Y. / Wang, W. / Cao, P. / Xia, Z. / Johnstone, S. / Yang, X. / Yu, T. / Sharkov, N. / Walker, N. / Tu, H. / Shen, W. / Wang, Z. |
---|
履歴 | 登録 | 2012年6月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2012年12月12日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2018年6月6日 | Group: Data collection / カテゴリ: diffrn_radiation_wavelength / diffrn_source / Item: _diffrn_source.pdbx_wavelength_list |
---|
改定 1.2 | 2021年5月19日 | Group: Derived calculations / Source and taxonomy / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / entity_src_gen / pdbx_entity_nonpoly / struct_site Item: _chem_comp.name / _entity.pdbx_description ..._chem_comp.name / _entity.pdbx_description / _entity_src_gen.host_org_common_name / _entity_src_gen.pdbx_host_org_cell_line / _entity_src_gen.pdbx_host_org_strain / _pdbx_entity_nonpoly.name / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
---|
|
---|