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Structure paper

TitleAn Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition
Journal, issue, pagesTo be published
Publish dateJun 1, 2012 (structure data deposition date)
AuthorsTang, J. / Majeti, J. / Sudom, A. / Xiong, Y. / Lu, M. / Liu, Q. / Higbee, J. / Zhang, Y. / Wang, Y. / Wang, W. ...Tang, J. / Majeti, J. / Sudom, A. / Xiong, Y. / Lu, M. / Liu, Q. / Higbee, J. / Zhang, Y. / Wang, Y. / Wang, W. / Cao, P. / Xia, Z. / Johnstone, S. / Yang, X. / Yu, T. / Sharkov, N. / Walker, N. / Tu, H. / Shen, W. / Wang, Z. / Min, X.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.4 - 2.9 Å
Structure data

PDB-4ffv:
Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-4ffw:
Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-715:
(2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A

Source
  • rattus norvegicus (Norway rat)
  • mus musculus (house mouse)
KeywordsHYDROLASE/Immune System / INHIBITOR / hydrolase / HYDROLASE-Immune System / INHIBITOR complex

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