Entry | Database: PDB / ID: 4fao |
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Title | Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex |
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Components | - Activin receptor type-2B
- Growth/differentiation factor 2
- Serine/threonine-protein kinase receptor R3
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Keywords | SIGNALING PROTEIN/SIGNALING PROTEIN / tgf-beta / CTK / cystine knot / extracellular domain / receptor / SIGNALING PROTEIN-SIGNALING PROTEIN complex |
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Function / homology | Function and homology information
Regulation of signaling by NODAL / activin receptor activity, type II / lymphatic endothelial cell differentiation / regulation of endothelial cell proliferation / positive regulation of activin receptor signaling pathway / activin receptor activity / negative regulation of endothelial cell differentiation / dorsal aorta morphogenesis / positive regulation of epithelial cell differentiation / blood vessel maturation ...Regulation of signaling by NODAL / activin receptor activity, type II / lymphatic endothelial cell differentiation / regulation of endothelial cell proliferation / positive regulation of activin receptor signaling pathway / activin receptor activity / negative regulation of endothelial cell differentiation / dorsal aorta morphogenesis / positive regulation of epithelial cell differentiation / blood vessel maturation / venous blood vessel development / positive regulation of cartilage development / transforming growth factor beta receptor activity / lymphangiogenesis / positive regulation of chondrocyte differentiation / BMP receptor complex / retina vasculature development in camera-type eye / BMP receptor activity / blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of endothelial cell differentiation / activin receptor activity, type I / embryonic foregut morphogenesis / transforming growth factor beta receptor activity, type I / activin receptor complex / negative regulation of focal adhesion assembly / endothelial tube morphogenesis / positive regulation of bicellular tight junction assembly / regulation of blood vessel endothelial cell migration / artery development / receptor protein serine/threonine kinase / transmembrane receptor protein serine/threonine kinase activity / Signaling by BMP / activin binding / cellular response to BMP stimulus / activin receptor signaling pathway / Signaling by Activin / positive regulation of BMP signaling pathway / Signaling by NODAL / negative regulation of cell adhesion / kinase activator activity / transforming growth factor beta binding / gastrulation with mouth forming second / dorsal/ventral pattern formation / pancreas development / blood circulation / cartilage development / determination of left/right symmetry / wound healing, spreading of epidermal cells / skeletal system morphogenesis / negative regulation of cold-induced thermogenesis / insulin secretion / blood vessel morphogenesis / negative regulation of endothelial cell migration / anterior/posterior pattern specification / cell surface receptor protein serine/threonine kinase signaling pathway / endocardial cushion morphogenesis / organ growth / branching involved in blood vessel morphogenesis / positive regulation of Notch signaling pathway / negative regulation of DNA replication / roof of mouth development / regulation of DNA replication / SMAD binding / growth factor binding / negative regulation of endothelial cell proliferation / odontogenesis of dentin-containing tooth / mesoderm development / positive regulation of SMAD protein signal transduction / negative regulation of blood vessel endothelial cell migration / blood vessel remodeling / vasculogenesis / BMP signaling pathway / positive regulation of bone mineralization / positive regulation of osteoblast differentiation / response to glucose / cellular response to transforming growth factor beta stimulus / positive regulation of endothelial cell proliferation / protein serine/threonine/tyrosine kinase activity / protein serine/threonine kinase activator activity / negative regulation of angiogenesis / negative regulation of cell migration / ossification / transforming growth factor beta receptor signaling pathway / post-embryonic development / kidney development / cytokine activity / positive regulation of interleukin-8 production / growth factor activity / lung development / negative regulation of cell growth / cellular response to growth factor stimulus / regulation of blood pressure / osteoblast differentiation / positive regulation of angiogenesis / heart development / angiogenesis / intracellular iron ion homeostasis / in utero embryonic development / transcription by RNA polymerase II / receptor complexSimilarity search - Function TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Transforming growth factor-beta (TGF-beta) family ...TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Transforming growth factor-beta (TGF-beta) family / Activin types I and II receptor domain / Activin types I and II receptor domain / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / CD59 / CD59 / Ser/Thr protein kinase, TGFB receptor / Snake toxin-like superfamily / Cystine-knot cytokine / Ribbon / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 3.357 Å |
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Authors | Townson, S.A. / Martinez-Hackert, E. / Greppi, C. / Lowden, P. / Sako, D. / Liu, J. / Ucran, J.A. / Liharska, K. / Underwood, K.W. / Seehra, J. ...Townson, S.A. / Martinez-Hackert, E. / Greppi, C. / Lowden, P. / Sako, D. / Liu, J. / Ucran, J.A. / Liharska, K. / Underwood, K.W. / Seehra, J. / Kumar, R. / Grinberg, A.V. |
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Citation | Journal: J.Biol.Chem. / Year: 2012 Title: Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex. Authors: Townson, S.A. / Martinez-Hackert, E. / Greppi, C. / Lowden, P. / Sako, D. / Liu, J. / Ucran, J.A. / Liharska, K. / Underwood, K.W. / Seehra, J. / Kumar, R. / Grinberg, A.V. |
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History | Deposition | May 22, 2012 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jun 20, 2012 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 25, 2012 | Group: Database references |
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Revision 1.2 | Aug 29, 2012 | Group: Database references |
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Revision 1.3 | Jul 29, 2020 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Derived calculations / Structure summary Category: chem_comp / database_PDB_caveat ...chem_comp / database_PDB_caveat / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details Description: Carbohydrate remediation / Provider: repository / Type: Remediation |
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Revision 1.4 | Apr 3, 2024 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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