PROTEIN BINDING / Calmodulin (CaM) / Intrinsically unstructured proteins / Protein kinase C (PKC) / Neuromodulin / Growth associated protein -43 (GAP-43) / Long Term Potentiation (LTP) / Long Term Depression (LTD) / IQ motif
機能・相同性
機能・相同性情報
L1CAM interactions / axon choice point recognition / CaMK IV-mediated phosphorylation of CREB / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Glycogen breakdown (glycogenolysis) / Activation of RAC1 downstream of NMDARs / Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / Activation of Ca-permeable Kainate Receptor ...L1CAM interactions / axon choice point recognition / CaMK IV-mediated phosphorylation of CREB / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Glycogen breakdown (glycogenolysis) / Activation of RAC1 downstream of NMDARs / Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / Activation of Ca-permeable Kainate Receptor / CLEC7A (Dectin-1) induces NFAT activation / regulation of postsynaptic specialization assembly / Synthesis of IP3 and IP4 in the cytosol / RHO GTPases activate PAKs / Calmodulin induced events / Inactivation, recovery and regulation of the phototransduction cascade / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / Calcineurin activates NFAT / eNOS activation / Ion transport by P-type ATPases / Unblocking of NMDA receptors, glutamate binding and activation / Protein methylation / RAF activation / VEGFR2 mediated vascular permeability / lysophosphatidic acid binding / RAS processing / Smooth Muscle Contraction / Ca2+ pathway / negative regulation of calcium ion transmembrane transporter activity / phosphatidylinositol phosphate binding / FCERI mediated Ca+2 mobilization / RHO GTPases activate IQGAPs / Extra-nuclear estrogen signaling / RAF/MAP kinase cascade / PKA activation / growth cone membrane / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / Platelet degranulation / glial cell differentiation / : / tissue regeneration / regulation of filopodium assembly / Stimuli-sensing channels / establishment of protein localization to mitochondrial membrane / Ion homeostasis / type 3 metabotropic glutamate receptor binding / filopodium membrane / regulation of growth / regulation of synaptic vesicle endocytosis / axon regeneration / negative regulation of high voltage-gated calcium channel activity / positive regulation of cyclic-nucleotide phosphodiesterase activity / organelle localization by membrane tethering / negative regulation of calcium ion export across plasma membrane / regulation of synaptic vesicle exocytosis / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / response to corticosterone / nitric-oxide synthase binding / positive regulation of ryanodine-sensitive calcium-release channel activity / phosphatidylserine binding / protein phosphatase activator activity / positive regulation of phosphoprotein phosphatase activity / adenylate cyclase binding / catalytic complex / detection of calcium ion / regulation of cardiac muscle contraction / negative regulation of ryanodine-sensitive calcium-release channel activity / GABA-ergic synapse / calcium channel inhibitor activity / cellular response to interferon-beta / cell fate commitment / phosphatidylinositol 3-kinase binding / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / enzyme regulator activity / positive regulation of protein dephosphorylation / regulation of calcium-mediated signaling / regulation of ryanodine-sensitive calcium-release channel activity / titin binding / potassium ion transmembrane transport / voltage-gated potassium channel complex / sperm midpiece / calcium channel complex / response to amphetamine / activation of adenylate cyclase activity / adenylate cyclase activator activity / nitric-oxide synthase regulator activity / regulation of heart rate / sarcomere / protein serine/threonine kinase activator activity / regulation of cytokinesis / positive regulation of nitric-oxide synthase activity / cell periphery / mitochondrial membrane / calcium-mediated signaling / axon guidance / positive regulation of receptor signaling pathway via JAK-STAT 類似検索 - 分子機能
Neuromodulin (GAP-43) / Neuromodulin (GAP-43), C-terminal / Neuromodulin, palmitoylation site / Neuromodulin gap junction N-terminal / Neuromodulin, phosphorylation site / Neuromodulin / Gap junction protein N-terminal region / Neuromodulin (GAP-43) signature 1. / Neuromodulin (GAP-43) signature 2. / IQ calmodulin-binding motif ...Neuromodulin (GAP-43) / Neuromodulin (GAP-43), C-terminal / Neuromodulin, palmitoylation site / Neuromodulin gap junction N-terminal / Neuromodulin, phosphorylation site / Neuromodulin / Gap junction protein N-terminal region / Neuromodulin (GAP-43) signature 1. / Neuromodulin (GAP-43) signature 2. / IQ calmodulin-binding motif / Short calmodulin-binding motif containing conserved Ile and Gln residues. / IQ motif profile. / IQ motif, EF-hand binding site / EF-hand / Recoverin; domain 1 / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性
構造決定の手法: 単波長異常分散 / 解像度: 2.69→30 Å / Cor.coef. Fo:Fc: 0.787 / Cor.coef. Fo:Fc free: 0.664 / SU B: 7.702 / SU ML: 0.168 / 交差検証法: THROUGHOUT / ESU R: 0.084 / ESU R Free: 0.067 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.31817
1278
5.7 %
RANDOM
Rwork
0.27604
-
-
-
obs
0.2785
21094
94.74 %
-
溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: MASK