PROTEIN BINDING / Calmodulin (CaM) / Intrinsically unstructured proteins / Protein kinase C (PKC) / Neurogranin / Long Term Potentiation (LTP) / Long Term Depression (LTD) / IQ motif
Function / homology
Function and homology information
trans-Golgi network transport vesicle membrane / CaMK IV-mediated phosphorylation of CREB / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Glycogen breakdown (glycogenolysis) / Activation of RAC1 downstream of NMDARs / Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / Activation of Ca-permeable Kainate Receptor / CLEC7A (Dectin-1) induces NFAT activation ...trans-Golgi network transport vesicle membrane / CaMK IV-mediated phosphorylation of CREB / Cam-PDE 1 activation / CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde / Glycogen breakdown (glycogenolysis) / Activation of RAC1 downstream of NMDARs / Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / Activation of Ca-permeable Kainate Receptor / CLEC7A (Dectin-1) induces NFAT activation / Synthesis of IP3 and IP4 in the cytosol / RHO GTPases activate PAKs / Calmodulin induced events / Inactivation, recovery and regulation of the phototransduction cascade / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / Calcineurin activates NFAT / eNOS activation / Ion transport by P-type ATPases / Unblocking of NMDA receptors, glutamate binding and activation / Protein methylation / RAF activation / VEGFR2 mediated vascular permeability / RAS processing / Smooth Muscle Contraction / Ca2+ pathway / negative regulation of calcium ion transmembrane transporter activity / FCERI mediated Ca+2 mobilization / RHO GTPases activate IQGAPs / Extra-nuclear estrogen signaling / RAF/MAP kinase cascade / PKA activation / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / Platelet degranulation / telencephalon development / : / Stimuli-sensing channels / establishment of protein localization to mitochondrial membrane / phosphatidic acid binding / Ion homeostasis / type 3 metabotropic glutamate receptor binding / regulation of synaptic vesicle endocytosis / negative regulation of high voltage-gated calcium channel activity / positive regulation of cyclic-nucleotide phosphodiesterase activity / organelle localization by membrane tethering / negative regulation of calcium ion export across plasma membrane / regulation of synaptic vesicle exocytosis / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / postsynaptic modulation of chemical synaptic transmission / response to corticosterone / dendritic spine head / nitric-oxide synthase binding / positive regulation of ryanodine-sensitive calcium-release channel activity / protein phosphatase activator activity / associative learning / phosphatidylinositol-3,4,5-trisphosphate binding / positive regulation of phosphoprotein phosphatase activity / adenylate cyclase binding / catalytic complex / detection of calcium ion / regulation of cardiac muscle contraction / negative regulation of ryanodine-sensitive calcium-release channel activity / calcium channel inhibitor activity / cellular response to interferon-beta / phosphatidylinositol 3-kinase binding / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / enzyme regulator activity / positive regulation of protein dephosphorylation / regulation of calcium-mediated signaling / regulation of ryanodine-sensitive calcium-release channel activity / titin binding / potassium ion transmembrane transport / voltage-gated potassium channel complex / sperm midpiece / calcium channel complex / response to amphetamine / activation of adenylate cyclase activity / adenylate cyclase activator activity / nitric-oxide synthase regulator activity / regulation of heart rate / sarcomere / protein serine/threonine kinase activator activity / regulation of cytokinesis / positive regulation of nitric-oxide synthase activity / positive regulation of long-term synaptic potentiation / mitochondrial membrane / calcium-mediated signaling / positive regulation of receptor signaling pathway via JAK-STAT / spindle microtubule / synaptic vesicle membrane / cellular response to type II interferon / spindle pole / response to calcium ion / G2/M transition of mitotic cell cycle / calcium-dependent protein binding / disordered domain specific binding / myelin sheath Similarity search - Function
IQ calmodulin-binding motif / Short calmodulin-binding motif containing conserved Ile and Gln residues. / IQ motif profile. / IQ motif, EF-hand binding site / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair Similarity search - Domain/homology
Method to determine structure: SAD / Resolution: 2.7→30 Å / Cor.coef. Fo:Fc: 0.938 / Cor.coef. Fo:Fc free: 0.928 / SU B: 48.697 / SU ML: 0.344 / Cross valid method: THROUGHOUT / ESU R: 0.11 / ESU R Free: 0.068 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.27529
359
4.7 %
RANDOM
Rwork
0.2408
-
-
-
obs
0.24229
7200
99.21 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: MASK
Displacement parameters
Biso mean: 94.328 Å2
Baniso -1
Baniso -2
Baniso -3
1-
9.16 Å2
0 Å2
0 Å2
2-
-
9.16 Å2
0 Å2
3-
-
-
-18.31 Å2
Refinement step
Cycle: LAST / Resolution: 2.7→30 Å
Protein
Nucleic acid
Ligand
Solvent
Total
Num. atoms
1258
0
0
22
1280
Refine LS restraints
Refine-ID
Type
Dev ideal
Dev ideal target
Number
X-RAY DIFFRACTION
r_bond_refined_d
0.012
0.022
1270
X-RAY DIFFRACTION
r_angle_refined_deg
1.431
1.961
1696
X-RAY DIFFRACTION
r_dihedral_angle_1_deg
7.078
5
157
X-RAY DIFFRACTION
r_dihedral_angle_2_deg
44.177
25.735
68
X-RAY DIFFRACTION
r_dihedral_angle_3_deg
22.281
15
248
X-RAY DIFFRACTION
r_dihedral_angle_4_deg
14.972
15
8
X-RAY DIFFRACTION
r_chiral_restr
0.113
0.2
185
X-RAY DIFFRACTION
r_gen_planes_refined
0.005
0.02
955
X-RAY DIFFRACTION
r_mcbond_it
0.61
1.5
786
X-RAY DIFFRACTION
r_mcangle_it
1.179
2
1254
X-RAY DIFFRACTION
r_scbond_it
1.46
3
484
X-RAY DIFFRACTION
r_scangle_it
2.62
4.5
442
LS refinement shell
Resolution: 2.699→2.768 Å / Total num. of bins used: 20
Rfactor
Num. reflection
% reflection
Rfree
0.299
36
-
Rwork
0.227
514
-
obs
-
-
98.57 %
Refinement TLS params.
Method: refined / Refine-ID: X-RAY DIFFRACTION
ID
L11 (°2)
L12 (°2)
L13 (°2)
L22 (°2)
L23 (°2)
L33 (°2)
S11 (Å °)
S12 (Å °)
S13 (Å °)
S21 (Å °)
S22 (Å °)
S23 (Å °)
S31 (Å °)
S32 (Å °)
S33 (Å °)
T11 (Å2)
T12 (Å2)
T13 (Å2)
T22 (Å2)
T23 (Å2)
T33 (Å2)
Origin x (Å)
Origin y (Å)
Origin z (Å)
1
0.6377
-0.2558
0.2352
2.4316
0.8135
0.4821
0.0468
0.0085
0.1004
0.0179
-0.1618
0.196
0.1637
-0.0261
0.1149
0.418
-0.0091
0.0097
0.2941
0.004
0.3053
33.6416
10.3103
-0.5169
2
13.3378
-1.4557
-11.5597
2.8112
7.8156
19.476
0.0376
0.0411
-0.2894
0.0416
-0.3523
0.2375
-0.0075
-0.1892
0.3147
0.6125
0.0409
0.0669
0.2669
0.0499
0.0984
33.938
7.391
4.025
Refinement TLS group
ID
Refine-ID
Refine TLS-ID
Auth asym-ID
Auth seq-ID
1
X-RAY DIFFRACTION
1
A
1 - 176
2
X-RAY DIFFRACTION
2
A
201 - 222
+
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