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Open data
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Basic information
Entry | Database: PDB / ID: 4doh | ||||||
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Title | IL20/IL201/IL20R2 Ternary Complex | ||||||
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![]() | SIGNALING PROTEIN / IL10 Family cytokine receptor complex / Alpha helical cytokine fold Beta sandwhich receptor fold / Signaling Complex / extracellular | ||||||
Function / homology | ![]() interleukin-20 receptor binding / negative regulation of type IV hypersensitivity / interleukin-20 binding / interleukin-22 receptor binding / immune response-inhibiting signal transduction / positive regulation of keratinocyte differentiation / positive regulation of osteoclast differentiation / inflammatory response to antigenic stimulus / regulation of bone resorption / cytokine receptor activity ...interleukin-20 receptor binding / negative regulation of type IV hypersensitivity / interleukin-20 binding / interleukin-22 receptor binding / immune response-inhibiting signal transduction / positive regulation of keratinocyte differentiation / positive regulation of osteoclast differentiation / inflammatory response to antigenic stimulus / regulation of bone resorption / cytokine receptor activity / negative regulation of interleukin-2 production / Interleukin-20 family signaling / positive regulation of interleukin-4 production / positive regulation of epidermal cell differentiation / T cell homeostasis / positive regulation of interleukin-10 production / negative regulation of type II interferon production / T cell proliferation / negative regulation of T cell proliferation / positive regulation of intrinsic apoptotic signaling pathway / positive regulation of tyrosine phosphorylation of STAT protein / homeostasis of number of cells within a tissue / cytokine activity / cytokine-mediated signaling pathway / regulation of inflammatory response / membrane => GO:0016020 / extracellular space / extracellular region / plasma membrane Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Logsdon, N.J. / Walter, M.R. | ||||||
![]() | ![]() Title: Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. Authors: Logsdon, N.J. / Deshpande, A. / Harris, B.D. / Rajashankar, K.R. / Walter, M.R. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 226.8 KB | Display | ![]() |
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PDB format | ![]() | 186 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 503.2 KB | Display | ![]() |
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Full document | ![]() | 547 KB | Display | |
Data in XML | ![]() | 44.8 KB | Display | |
Data in CIF | ![]() | 60.2 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 | ![]()
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2 | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 17626.479 Da / Num. of mol.: 2 / Mutation: Q40N, Q134N, R111K, R113K Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #2: Protein | Mass: 23047.047 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #3: Protein | Mass: 25270.729 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #4: Sugar | ChemComp-NAG / #5: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.98 Å3/Da / Density % sol: 58.7 % |
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Crystal grow | Temperature: 298 K / Method: vapor diffusion, hanging drop / pH: 6.5 Details: 19% PEG 6000, 0.1M ADA, 0.1M MgCl2, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K |
-Data collection
Diffraction | Mean temperature: 298 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC QUANTUM 315 / Detector: CCD / Date: Oct 6, 2006 |
Radiation | Monochromator: Si 111 CHANNEL / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1 Å / Relative weight: 1 |
Reflection | Resolution: 2.8→50 Å / Num. all: 42596 / Num. obs: 38635 / % possible obs: 90.7 % / Observed criterion σ(F): 0 / Observed criterion σ(I): -3 |
Reflection shell | Resolution: 2.8→2.9 Å / % possible all: 90.7 |
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Processing
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Refinement | Method to determine structure: ![]()
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Refinement step | Cycle: LAST / Resolution: 2.8→50 Å
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