登録情報 | データベース: PDB / ID: 4dau |
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タイトル | Structure of 14-3-3 sigma in complex with PADI6 14-3-3 binding motif I |
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要素 | - 14-3-3 protein sigma
- Peptidylarginine Deiminase type VI
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キーワード | SIGNALING PROTEIN/PROTEIN BINDING / 14-3-3 fold / protein-protein interaction / SIGNALING PROTEIN-PROTEIN BINDING complex |
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機能・相同性 | 機能・相同性情報
regulation of translation by machinery localization / cytoplasm organization / protein-arginine deiminase / cortical granule / protein-arginine deiminase activity / embryonic cleavage / intermediate filament cytoskeleton / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation ...regulation of translation by machinery localization / cytoplasm organization / protein-arginine deiminase / cortical granule / protein-arginine deiminase activity / embryonic cleavage / intermediate filament cytoskeleton / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / keratinization / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation / establishment of skin barrier / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / Chromatin modifying enzymes / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / negative regulation of stem cell proliferation / RHO GTPases activate PKNs / cytoskeleton organization / protein kinase A signaling / protein sequestering activity / negative regulation of innate immune response / protein export from nucleus / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / positive regulation of protein export from nucleus / release of cytochrome c from mitochondria / stem cell proliferation / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / negative regulation of protein kinase activity / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of cell growth / regulation of cell cycle / cadherin binding / calcium ion binding / protein kinase binding / negative regulation of transcription by RNA polymerase II / signal transduction / extracellular space / extracellular exosome / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Protein-arginine deiminase / Protein-arginine deiminase, C-terminal / Protein-arginine deiminase (PAD), N-terminal / Protein-arginine deiminase (PAD), central domain / Protein-arginine deiminase, central domain superfamily / PAD, N-terminal domain superfamily / Protein-arginine deiminase (PAD) / Protein-arginine deiminase (PAD) N-terminal domain / Protein-arginine deiminase (PAD) middle domain / 14-3-3 domain ...Protein-arginine deiminase / Protein-arginine deiminase, C-terminal / Protein-arginine deiminase (PAD), N-terminal / Protein-arginine deiminase (PAD), central domain / Protein-arginine deiminase, central domain superfamily / PAD, N-terminal domain superfamily / Protein-arginine deiminase (PAD) / Protein-arginine deiminase (PAD) N-terminal domain / Protein-arginine deiminase (PAD) middle domain / 14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 protein sigma / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Cupredoxin / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 14-3-3 protein sigma / Protein-arginine deiminase type-6 / Protein-arginine deiminase type-6類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 解像度: 2 Å |
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データ登録者 | Rose, R. / Rose, M. / Ottmann, C. |
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引用 | ジャーナル: J.Struct.Biol. / 年: 2012 タイトル: Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI. 著者: Rose, R. / Rose, M. / Ottmann, C. |
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履歴 | 登録 | 2012年1月13日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年6月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年10月24日 | Group: Database references |
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改定 1.2 | 2023年9月13日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details |
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