Entry Database : PDB / ID : 4cxi Structure visualization Downloads & linksTitle BTB domain of KEAP1 ComponentsKELCH-LIKE ECH-ASSOCIATED PROTEIN 1 Details Keywords TRANSCRIPTIONFunction / homology Function and homology informationFunction Domain/homology Component
regulation of epidermal cell differentiation / negative regulation of response to oxidative stress / Nuclear events mediated by NFE2L2 / Cul3-RING ubiquitin ligase complex / centriolar satellite / ubiquitin-like ligase-substrate adaptor activity / cellular response to interleukin-4 / inclusion body / regulation of autophagy / actin filament ... regulation of epidermal cell differentiation / negative regulation of response to oxidative stress / Nuclear events mediated by NFE2L2 / Cul3-RING ubiquitin ligase complex / centriolar satellite / ubiquitin-like ligase-substrate adaptor activity / cellular response to interleukin-4 / inclusion body / regulation of autophagy / actin filament / negative regulation of DNA-binding transcription factor activity / disordered domain specific binding / KEAP1-NFE2L2 pathway / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Antigen processing: Ubiquitination & Proteasome degradation / Neddylation / cellular response to oxidative stress / midbody / ubiquitin-dependent protein catabolic process / in utero embryonic development / RNA polymerase II-specific DNA-binding transcription factor binding / Potential therapeutics for SARS / Ub-specific processing proteases / protein ubiquitination / endoplasmic reticulum / nucleoplasm / identical protein binding / cytosol / cytoplasm Similarity search - Function Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Potassium Channel Kv1.1; Chain A / Potassium Channel Kv1.1; Chain A / Kelch repeat type 1 ... Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Potassium Channel Kv1.1; Chain A / Potassium Channel Kv1.1; Chain A / Kelch repeat type 1 / Kelch motif / Kelch-type beta propeller / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / SKP1/BTB/POZ domain superfamily / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.35 Å DetailsAuthors Cleasby, A. / Yon, J. / Day, P.J. / Richardson, C. / Tickle, I.J. / Williams, P.A. / Callahan, J.F. / Carr, R. / Concha, N. / Kerns, J.K. ...Cleasby, A. / Yon, J. / Day, P.J. / Richardson, C. / Tickle, I.J. / Williams, P.A. / Callahan, J.F. / Carr, R. / Concha, N. / Kerns, J.K. / Qi, H. / Sweitzer, T. / Ward, P. / Davies, T.G. CitationJournal : Plos One / Year : 2014Title : Structure of the Btb Domain of Keap1 and its Interaction with the Triterpenoid Antagonist Cddo.Authors : Cleasby, A. / Yon, J. / Day, P.J. / Richardson, C. / Tickle, I.J. / Williams, P.A. / Callahan, J.F. / Carr, R. / Concha, N. / Kerns, J.K. / Qi, H. / Sweitzer, T. / Ward, P. / Davies, T.G. History Deposition Apr 7, 2014 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jun 18, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Dec 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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