登録情報 データベース : PDB / ID : 4clb 構造の表示 ダウンロードとリンクタイトル N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH IBET-295 要素BROMODOMAIN-CONTAINING PROTEIN 4 詳細 キーワード TRANSCRIPTION機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RNA polymerase II C-terminal domain binding / P-TEFb complex binding / negative regulation of DNA damage checkpoint / host-mediated suppression of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / RNA polymerase II CTD heptapeptide repeat kinase activity / : / histone reader activity / condensed nuclear chromosome ... RNA polymerase II C-terminal domain binding / P-TEFb complex binding / negative regulation of DNA damage checkpoint / host-mediated suppression of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / RNA polymerase II CTD heptapeptide repeat kinase activity / : / histone reader activity / condensed nuclear chromosome / transcription coregulator activity / positive regulation of transcription elongation by RNA polymerase II / p53 binding / chromosome / regulation of inflammatory response / histone binding / Potential therapeutics for SARS / transcription coactivator activity / positive regulation of canonical NF-kappaB signal transduction / transcription cis-regulatory region binding / chromatin remodeling / protein serine/threonine kinase activity / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / chromatin / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus 類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / Brdt, bromodomain, repeat I / Brdt, bromodomain, repeat II / NET domain superfamily / NET domain profile. / : / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / Brdt, bromodomain, repeat I / Brdt, bromodomain, repeat II / NET domain superfamily / NET domain profile. / : / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / bromo domain / Bromodomain (BrD) profile. / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 HOMO SAPIENS (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.6 Å 詳細データ登録者 Chung, C. / Atkinson, S. 引用ジャーナル : Medchemcomm / 年 : 2014タイトル : The Structure Based Design of Dual Hdac/Bet Inhibitors as Novel Epigenetic Probes.著者 : Atkinson, S.J. / Soden, P.E. / Angell, D.C. / Bantscheff, M. / Chung, C. / Giblin, K.A. / Smithers, N. / Furze, R.C. / Gordon, L. / Drewes, G. / Rioja, I. / Witherington, J. / Parr, N.J. / Prinjha, R.K. 履歴 登録 2014年1月13日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2014年12月24日 Provider : repository / タイプ : Initial release改定 1.1 2024年5月8日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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