Entry Database : PDB / ID : 4cdk Structure visualization Downloads & linksTitle Structure of ZNRF3-RSPO1 ComponentsE3 UBIQUITIN-PROTEIN LIGASE ZNRF3 R-SPONDIN-1 DetailsKeywords LIGASE / WNT SIGNALING / ADULT STEM CELLS / E3 LIGASE / PROTEASE-ASSOCIATED DOMAIN / ZINC RING FINGER / LGR5 / R-SPONDINFunction / homology Function and homology informationFunction Domain/homology Component
regulation of Wnt signaling pathway, planar cell polarity pathway / Wnt receptor catabolic process / negative regulation of non-canonical Wnt signaling pathway / Regulation of FZD by ubiquitination / regulation of receptor internalization / frizzled binding / regulation of canonical Wnt signaling pathway / limb development / negative regulation of Wnt signaling pathway / positive regulation of Wnt signaling pathway ... regulation of Wnt signaling pathway, planar cell polarity pathway / Wnt receptor catabolic process / negative regulation of non-canonical Wnt signaling pathway / Regulation of FZD by ubiquitination / regulation of receptor internalization / frizzled binding / regulation of canonical Wnt signaling pathway / limb development / negative regulation of Wnt signaling pathway / positive regulation of Wnt signaling pathway / Regulation of FZD by ubiquitination / stem cell proliferation / G protein-coupled receptor binding / RING-type E3 ubiquitin transferase / negative regulation of canonical Wnt signaling pathway / Wnt signaling pathway / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / positive regulation of canonical Wnt signaling pathway / heparin binding / ubiquitin-dependent protein catabolic process / protein ubiquitination / positive regulation of protein phosphorylation / signaling receptor binding / extracellular region / nucleus / metal ion binding / plasma membrane Similarity search - Function E3 ubiquitin-protein ligase ZNRF3, Zinc finger, RING-type / ZNRF-3, ectodomain / ZNRF-3 Ectodomain / R-spondin, Fu-CRD domain / Furin-like repeat, cysteine-rich / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 / Ring finger domain / Glucose Oxidase; domain 1 - #30 / Glucose Oxidase; domain 1 ... E3 ubiquitin-protein ligase ZNRF3, Zinc finger, RING-type / ZNRF-3, ectodomain / ZNRF-3 Ectodomain / R-spondin, Fu-CRD domain / Furin-like repeat, cysteine-rich / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 / Ring finger domain / Glucose Oxidase; domain 1 - #30 / Glucose Oxidase; domain 1 / Thrombospondin type-1 (TSP1) repeat superfamily / Thrombospondin type-1 (TSP1) repeat profile. / Thrombospondin type 1 repeats / Thrombospondin type-1 (TSP1) repeat / Furin-like repeat / Furin-like repeats / Ring finger / Growth factor receptor cysteine-rich domain superfamily / Zinc finger RING-type profile. / 3-Layer(bba) Sandwich / Zinc finger, RING-type / Ribbon / Zinc finger, RING/FYVE/PHD-type / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species MUS MUSCULUS (house mouse)HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Peng, W.C. / de Lau, W. / Madoori, P.K. / Forneris, F. / Granneman, J.C.M. / Clevers, H. / Gros, P. CitationJournal : Plos One / Year : 2013Title : Structures of Wnt-Antagonist Znrf3 and its Complex with R-Spondin 1 and Implications for Signaling.Authors : Peng, W.C. / De Lau, W. / Madoori, P.K. / Forneris, F. / Granneman, J.C.M. / Clevers, H. / Gros, P. History Deposition Nov 1, 2013 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jan 8, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Apr 3, 2019 Group : Data collection / Other / Source and taxonomyCategory : entity_src_gen / pdbx_database_proc / pdbx_database_statusItem : _entity_src_gen.pdbx_host_org_cell_line / _pdbx_database_status.recvd_author_approval
Show all Show less Remark 700 SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AA" IN EACH CHAIN ON SHEET RECORDS BELOW ... SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AA" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 7-STRANDED BARREL THIS IS REPRESENTED BY A 8-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL. THE SHEETS PRESENTED AS "BA" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 7-STRANDED BARREL THIS IS REPRESENTED BY A 8-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL. THE SHEETS PRESENTED AS "DA" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 7-STRANDED BARREL THIS IS REPRESENTED BY A 8-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL.