Entry Database : PDB / ID : 4cd3 Structure visualization Downloads & linksTitle RnNTPDase2 X4 variant in complex with PSB-071 ComponentsECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2 Details Keywords HYDROLASE / APYRASE / ATPASE / PURINERGIC SIGNALLING / DRUG DESIGN / INHIBITOR / NTPDASEFunction / homology Function and homology informationFunction Domain/homology Component
purine ribonucleoside diphosphate catabolic process / Phosphate bond hydrolysis by NTPDase proteins / nucleoside diphosphate catabolic process / UDP phosphatase activity / nucleoside diphosphate phosphatase activity / ADP phosphatase activity / GDP phosphatase activity / cellular response to interferon-alpha / response to auditory stimulus / cell projection membrane ... purine ribonucleoside diphosphate catabolic process / Phosphate bond hydrolysis by NTPDase proteins / nucleoside diphosphate catabolic process / UDP phosphatase activity / nucleoside diphosphate phosphatase activity / ADP phosphatase activity / GDP phosphatase activity / cellular response to interferon-alpha / response to auditory stimulus / cell projection membrane / cellular response to interleukin-6 / Hydrolases; Acting on acid anhydrides; In phosphorus-containing anhydrides / basement membrane / ribonucleoside triphosphate phosphatase activity / platelet activation / cellular response to tumor necrosis factor / cell body / cellular response to lipopolysaccharide / G protein-coupled receptor signaling pathway / cell surface / ATP hydrolysis activity / ATP binding / identical protein binding / plasma membrane Similarity search - Function GDA1/CD39 family of nucleoside phosphatases signature. / Exopolyphosphatase. Domain 2 / Nucleoside phosphatase GDA1/CD39 / GDA1/CD39 (nucleoside phosphatase) family / ATPase, nucleotide binding domain / Nucleotidyltransferase; domain 5 / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species RATTUS NORVEGICUS (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / OTHER / Resolution : 2.19 Å DetailsAuthors Zebisch, M. / Schaefer, P. / Straeter, N. CitationJournal : J.Struct.Biol. / Year : 2014Title : Crystal Structure of Ntpdase2 in Complex with the Sulfoanthraquinone Inhibitor Psb-071.Authors : Zebisch, M. / Baqi, Y. / Schafer, P. / Muller, C.E. / Strater, N. History Deposition Oct 29, 2013 Deposition site : PDBE / Processing site : PDBERevision 1.0 Feb 12, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Mar 12, 2014 Group : Database references
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