登録情報 | データベース: PDB / ID: 4cbs |
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タイトル | X-ray structure of quintuple mutant of human alanine glyoxylate aminotransferase, AGXT_RHEAM |
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要素 | SERINE--PYRUVATE AMINOTRANSFERASE |
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キーワード | TRANSFERASE / PRIMARY HIPEROXALURIA TYPE I / PROTEIN STABILIZATION |
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機能・相同性 | 機能・相同性情報
oxalic acid secretion / serine-pyruvate transaminase / alanine-glyoxylate transaminase / glyoxylate metabolic process / glycine biosynthetic process, by transamination of glyoxylate / L-alanine catabolic process / serine-pyruvate transaminase activity / alanine-glyoxylate transaminase activity / Glyoxylate metabolism and glycine degradation / L-serine metabolic process ...oxalic acid secretion / serine-pyruvate transaminase / alanine-glyoxylate transaminase / glyoxylate metabolic process / glycine biosynthetic process, by transamination of glyoxylate / L-alanine catabolic process / serine-pyruvate transaminase activity / alanine-glyoxylate transaminase activity / Glyoxylate metabolism and glycine degradation / L-serine metabolic process / L-cysteine catabolic process / glyoxylate catabolic process / transaminase activity / amino acid binding / peroxisomal matrix / Notch signaling pathway / Peroxisomal protein import / pyridoxal phosphate binding / peroxisome / intracellular membrane-bounded organelle / protein homodimerization activity / identical protein binding / cytosol類似検索 - 分子機能 Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase / Aminotransferase class-V, pyridoxal-phosphate binding site / Aminotransferases class-V pyridoxal-phosphate attachment site. / Aminotransferase class V domain / Aminotransferase class-V / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase; domain 2 / Type I PLP-dependent aspartate aminotransferase-like (Major domain) / Pyridoxal phosphate-dependent transferase, small domain ...Serine-pyruvate aminotransferase/2-aminoethylphosphonate-pyruvate transaminase / Aminotransferase class-V, pyridoxal-phosphate binding site / Aminotransferases class-V pyridoxal-phosphate attachment site. / Aminotransferase class V domain / Aminotransferase class-V / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase, domain 1 / Aspartate Aminotransferase; domain 2 / Type I PLP-dependent aspartate aminotransferase-like (Major domain) / Pyridoxal phosphate-dependent transferase, small domain / Pyridoxal phosphate-dependent transferase, major domain / Pyridoxal phosphate-dependent transferase / Alpha-Beta Complex / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 PYRIDOXAL-5'-PHOSPHATE / Alanine--glyoxylate aminotransferase類似検索 - 構成要素 |
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生物種 | HOMO SAPIENS (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
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データ登録者 | Yunta, C. / Albert, A. |
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引用 | ジャーナル: Biochem.J. / 年: 2014 タイトル: The Consensus-Based Approach for Gene/Enzyme Replacement Therapies and Crystallization Strategies: The Case of Human Alanine:Glyoxylate Aminotransferase. 著者: Mesa-Torres, N. / Yunta, C. / Fabelo-Rosa, I. / Gonzalez-Rubio, J.M. / Sanchez-Ruiz, J.M. / Salido, E. / Albert, A. / Pey, A.L. |
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履歴 | 登録 | 2013年10月16日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2014年7月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年9月3日 | Group: Database references |
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改定 1.2 | 2019年10月16日 | Group: Data collection / Derived calculations ...Data collection / Derived calculations / Experimental preparation / Other カテゴリ: exptl_crystal_grow / pdbx_database_status ...exptl_crystal_grow / pdbx_database_status / reflns_shell / struct_conn Item: _exptl_crystal_grow.method / _exptl_crystal_grow.temp ..._exptl_crystal_grow.method / _exptl_crystal_grow.temp / _pdbx_database_status.status_code_sf / _reflns_shell.Rmerge_I_obs / _struct_conn.pdbx_leaving_atom_flag |
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改定 1.3 | 2023年12月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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