登録情報 データベース : PDB / ID : 4bjx 構造の表示 ダウンロードとリンクタイトル N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH GSK1324726A (I-BET726) 要素BROMODOMAIN-CONTAINING PROTEIN 4 詳細 キーワード DNA BINDING PROTEIN / INHIBITOR / HISTONE / EPIGENETIC READER機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ... RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus 類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / : / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / : / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 HOMO SAPIENS (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.59 Å 詳細データ登録者 Chung, C. 引用ジャーナル : Plos One / 年 : 2013タイトル : Bet Inhibition Silences Expression of Mycn and Bcl2 and Induces Cytotoxicity in Neuroblastoma Tumor Models.著者: Wyce, A. / Ganji, G. / Smitheman, K.N. / Chung, C. / Korenchuk, S. / Bai, Y. / Barbash, O. / Le, B. / Craggs, P.D. / Mccabe, M.T. / Kennedy-Wilson, K.M. / Sanchez, L.V. / Gosmini, R.L. / ... 著者 : Wyce, A. / Ganji, G. / Smitheman, K.N. / Chung, C. / Korenchuk, S. / Bai, Y. / Barbash, O. / Le, B. / Craggs, P.D. / Mccabe, M.T. / Kennedy-Wilson, K.M. / Sanchez, L.V. / Gosmini, R.L. / Parr, N. / Mchugh, C.F. / Dhanak, D. / Prinjha, R.K. / Auger, K.R. / Tummino, P.J. 履歴 登録 2013年4月20日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2013年10月2日 Provider : repository / タイプ : Initial release改定 1.1 2014年4月23日 Group : Database references / Source and taxonomy改定 1.2 2019年5月15日 Group : Data collection / Experimental preparation / Otherカテゴリ : exptl_crystal_grow / pdbx_database_proc / pdbx_database_statusItem : _exptl_crystal_grow.temp / _pdbx_database_status.recvd_author_approval改定 1.3 2024年5月8日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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