Entry Database : PDB / ID : 4bgq Structure visualization Downloads & linksTitle Crystal structure of the human CDKL5 kinase domain ComponentsCYCLIN-DEPENDENT KINASE-LIKE 5 Details Keywords TRANSFERASE / PHOSPHO-MIMETIC / KINASEFunction / homology Function and homology informationFunction Domain/homology Component
regulation of cilium assembly / regulation of dendrite development / ciliary tip / positive regulation of dendrite morphogenesis / regulation of postsynapse organization / positive regulation of dendritic spine development / dendritic growth cone / postsynaptic density, intracellular component / positive regulation of axon extension / cyclin-dependent kinase ... regulation of cilium assembly / regulation of dendrite development / ciliary tip / positive regulation of dendrite morphogenesis / regulation of postsynapse organization / positive regulation of dendritic spine development / dendritic growth cone / postsynaptic density, intracellular component / positive regulation of axon extension / cyclin-dependent kinase / cyclin-dependent protein serine/threonine kinase activity / dendrite cytoplasm / ciliary basal body / positive regulation of GTPase activity / neuron migration / modulation of chemical synaptic transmission / small GTPase binding / kinase activity / protein autophosphorylation / protein kinase activity / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / glutamatergic synapse / perinuclear region of cytoplasm / nucleoplasm / ATP binding / nucleus Similarity search - Function Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. ... Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2 Å DetailsAuthors Canning, P. / Krojer, T. / Goubin, S. / Mahajan, P. / Vollmar, M. / Pike, A.C.W. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Bullock, A. CitationJournal : Cell Rep / Year : 2018Title : CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.Authors : Canning, P. / Park, K. / Goncalves, J. / Li, C. / Howard, C.J. / Sharpe, T.D. / Holt, L.J. / Pelletier, L. / Bullock, A.N. / Leroux, M.R. History Deposition Mar 28, 2013 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 8, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Jan 24, 2018 Group : Database references / Category : citation_author / Item : _citation_author.nameRevision 1.2 Mar 30, 2022 Group : Database references / Derived calculations / OtherCategory : citation / citation_author ... citation / citation_author / database_2 / pdbx_database_status / struct_site Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.3 Dec 20, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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