- PDB-4bfr: Discovery and Optimization of Pyrimidone Indoline Amide PI3Kbeta ... -
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IDまたはキーワード:
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基本情報
登録情報
データベース: PDB / ID: 4bfr
タイトル
Discovery and Optimization of Pyrimidone Indoline Amide PI3Kbeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers
要素
PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC S SUBUNIT BETA ISOFORM
キーワード
TRANSFERASE / INHIBITOR
機能・相同性
機能・相同性情報
IRS-mediated signalling / Signaling by ALK / negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway / Tie2 Signaling / PI3K/AKT activation / PI3K Cascade / Role of LAT2/NTAL/LAB on calcium mobilization / Downstream signal transduction / GPVI-mediated activation cascade / negative regulation of sprouting angiogenesis ...IRS-mediated signalling / Signaling by ALK / negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway / Tie2 Signaling / PI3K/AKT activation / PI3K Cascade / Role of LAT2/NTAL/LAB on calcium mobilization / Downstream signal transduction / GPVI-mediated activation cascade / negative regulation of sprouting angiogenesis / Role of phospholipids in phagocytosis / negative regulation of vascular endothelial growth factor signaling pathway / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / RAF/MAP kinase cascade / Interleukin receptor SHC signaling / Synthesis of PIPs at the plasma membrane / PIP3 activates AKT signaling / Downstream TCR signaling / Regulation of signaling by CBL / positive regulation of neutrophil apoptotic process / regulation of cell-matrix adhesion / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / Interleukin-3, Interleukin-5 and GM-CSF signaling / RET signaling / embryonic cleavage / angiogenesis involved in wound healing / VEGFA-VEGFR2 Pathway / sphingosine-1-phosphate receptor signaling pathway / phosphatidylinositol 3-kinase complex, class IA / phosphatidylinositol 3-kinase complex / endothelial cell proliferation / 1-phosphatidylinositol-4-phosphate 3-kinase activity / 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity / phosphatidylinositol-4,5-bisphosphate 3-kinase / DAP12 signaling / phosphatidylinositol-3-phosphate biosynthetic process / negative regulation of MAPK cascade / 1-phosphatidylinositol-3-kinase activity / homophilic cell adhesion via plasma membrane adhesion molecules / positive regulation of Rac protein signal transduction / phosphatidylinositol-mediated signaling / phosphatidylinositol phosphate biosynthetic process / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / insulin receptor substrate binding / phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of endothelial cell migration / phosphorylation / response to ischemia / brush border membrane / platelet activation / autophagy / intracellular calcium ion homeostasis / endocytosis / positive regulation of nitric oxide biosynthetic process / cell migration / kinase activity / midbody / non-specific serine/threonine protein kinase / protein serine kinase activity / positive regulation of gene expression / nucleolus / nucleoplasm / ATP binding / nucleus / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能
解像度: 2.8→56 Å / Cor.coef. Fo:Fc: 0.8932 / Cor.coef. Fo:Fc free: 0.8782 / SU R Cruickshank DPI: 1.126 / 交差検証法: THROUGHOUT / σ(F): 0 / SU R Blow DPI: 1.012 / SU Rfree Blow DPI: 0.356 / SU Rfree Cruickshank DPI: 0.366 詳細: IDEAL-DIST CONTACT TERM CONTACT SETUP. ALL ATOMS HAVE CCP4 ATOM TYPE FROM LIBRARY