+Open data
-Basic information
Entry | Database: PDB / ID: 452d | ||||||||||||||||||
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Title | ACRIDINE BINDING TO DNA | ||||||||||||||||||
Components | DNA (5'-D(*Keywords | DNA / INTERCALATION / GROOVE BINDING | Function / homology | Chem-9AD / DNA | Function and homology information Method | X-RAY DIFFRACTION / Resolution: 1.6 Å | Authors | Thorpe, J.H. / Todd, A.K. / Cardin, C.J. | Citation | Journal: J.Med.Chem. / Year: 1999 | Title: Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethlyamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray ...Title: Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethlyamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5Br-U)ACG)2 at 1.3-angstrom resolution Authors: Todd, A.K. / Adams, A. / Thorpe, J.H. / Denny, W.A. / Wakelin, L.P.G. / Cardin, C.J. History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 452d.cif.gz | 17.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb452d.ent.gz | 11 KB | Display | PDB format |
PDBx/mmJSON format | 452d.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 452d_validation.pdf.gz | 448.8 KB | Display | wwPDB validaton report |
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Full document | 452d_full_validation.pdf.gz | 456.7 KB | Display | |
Data in XML | 452d_validation.xml.gz | 3.4 KB | Display | |
Data in CIF | 452d_validation.cif.gz | 4 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/52/452d ftp://data.pdbj.org/pub/pdb/validation_reports/52/452d | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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Unit cell |
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Components on special symmetry positions |
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-Components
#1: DNA chain | Mass: 1809.217 Da / Num. of mol.: 1 / Source method: obtained synthetically | ||||
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#2: Chemical | #3: Chemical | ChemComp-MPD / ( | #4: Water | ChemComp-HOH / | |
-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION / Number of used crystals: 1 |
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-Sample preparation
Crystal | Density Matthews: 2.76 Å3/Da / Density % sol: 55.41 % |
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Crystal grow | Method: vapor diffusion, sitting drop / Details: VAPOR DIFFUSION, SITTING DROP |
-Data collection
Diffraction source | Source: ROTATING ANODE / Wavelength: 1.5418 |
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Detector | Detector: AREA DETECTOR |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.5418 Å / Relative weight: 1 |
Reflection | Resolution: 1.6→16 Å |
-Processing
Software | Name: SHELXL-97 / Classification: refinement | ||||||||||||
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Refinement | Resolution: 1.6→16 Å
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Refinement step | Cycle: LAST / Resolution: 1.6→16 Å
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