登録情報 データベース : PDB / ID : 3zn1 構造の表示 ダウンロードとリンクタイトル LSD1-CoREST in complex with PRLYLV peptide 要素LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A PEPTIDE REST COREPRESSOR 1 詳細キーワード OXIDOREDUCTASE/PEPTIDE / OXIDOREDUCTASE-PEPTIDE COMPLEX / DEMETHYLASE / TRANSCRIPTION FACTOR / CHROMATIN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of megakaryocyte differentiation / guanine metabolic process / regulation of DNA methylation-dependent heterochromatin formation / protein demethylation / [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase / FAD-dependent H3K4me/H3K4me3 demethylase activity / demethylase activity / telomeric repeat-containing RNA binding / histone H3K4 demethylase activity / muscle cell development ... positive regulation of megakaryocyte differentiation / guanine metabolic process / regulation of DNA methylation-dependent heterochromatin formation / protein demethylation / [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase / FAD-dependent H3K4me/H3K4me3 demethylase activity / demethylase activity / telomeric repeat-containing RNA binding / histone H3K4 demethylase activity / muscle cell development / neuron maturation / positive regulation of neural precursor cell proliferation / regulation of androgen receptor signaling pathway / MRF binding / DNA repair complex / DNA repair-dependent chromatin remodeling / nuclear androgen receptor binding / regulation of double-strand break repair via homologous recombination / positive regulation of neuroblast proliferation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / positive regulation of stem cell proliferation / negative regulation of DNA binding / histone H3K9 demethylase activity / negative regulation of DNA damage response, signal transduction by p53 class mediator / histone deacetylase complex / positive regulation of cell size / histone demethylase activity / positive regulation of epithelial to mesenchymal transition / cellular response to cAMP / response to fungicide / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / transcription repressor complex / erythrocyte differentiation / nuclear receptor coactivator activity / negative regulation of protein binding / positive regulation of protein ubiquitination / Regulation of PTEN gene transcription / HDACs deacetylate histones / promoter-specific chromatin binding / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / HDMs demethylate histones / negative regulation of DNA-binding transcription factor activity / cellular response to gamma radiation / cerebral cortex development / positive regulation of neuron projection development / transcription corepressor activity / regulation of protein localization / cellular response to UV / p53 binding / chromatin organization / positive regulation of cold-induced thermogenesis / flavin adenine dinucleotide binding / Factors involved in megakaryocyte development and platelet production / DNA-binding transcription factor binding / Estrogen-dependent gene expression / RNA polymerase II-specific DNA-binding transcription factor binding / transcription regulator complex / Potential therapeutics for SARS / chromosome, telomeric region / transcription coactivator activity / oxidoreductase activity / chromatin remodeling / negative regulation of gene expression / negative regulation of DNA-templated transcription / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / enzyme binding / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / identical protein binding / nucleus 類似検索 - 分子機能 Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1880 / : / : / Helical region in REST corepressor / ELM2 domain / ELM2 domain / ELM2 domain profile. / ELM2 / Histone lysine-specific demethylase / ATP synthase, gamma subunit, helix hairpin domain ... Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1880 / : / : / Helical region in REST corepressor / ELM2 domain / ELM2 domain / ELM2 domain profile. / ELM2 / Histone lysine-specific demethylase / ATP synthase, gamma subunit, helix hairpin domain / SWIRM domain / SWIRM domain / SWIRM domain profile. / : / SANT domain profile. / SANT domain / Amine oxidase / Flavin containing amine oxidoreductase / Myb-like DNA-binding domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain / Homeobox-like domain superfamily / FAD/NAD(P)-binding domain superfamily / Helix Hairpins / Arc Repressor Mutant, subunit A / Winged helix-like DNA-binding domain superfamily / Up-down Bundle / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 FLAVIN-ADENINE DINUCLEOTIDE / Lysine-specific histone demethylase 1A / REST corepressor 1 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.1 Å 詳細データ登録者 Tortorici, M. / Borrello, M.T. / Tardugno, M. / Chiarelli, L.R. / Pilotto, S. / Ciossani, G. / Vellore, N.A. / Cowan, J. / O'Connell, M. / Mai, A. ...Tortorici, M. / Borrello, M.T. / Tardugno, M. / Chiarelli, L.R. / Pilotto, S. / Ciossani, G. / Vellore, N.A. / Cowan, J. / O'Connell, M. / Mai, A. / Baron, R. / Ganesan, A. / Mattevi, A. 引用ジャーナル : Acs Chem.Biol. / 年 : 2013タイトル : Protein Recognition by Small Peptide Reversible Inhibitors of the Chromatin-Modifying Lsd1/Corest Lysine Demethylase.著者: Tortorici, M. / Borrello, M.T. / Tardugno, M. / Chiarelli, L.R. / Pilotto, S. / Ciossani, G. / Vellore, N.A. / Bailey, S.G. / Cowan, J. / O'Connell, M. / Crabb, S.J. / Packham, G.K. / Mai, A. ... 著者 : Tortorici, M. / Borrello, M.T. / Tardugno, M. / Chiarelli, L.R. / Pilotto, S. / Ciossani, G. / Vellore, N.A. / Bailey, S.G. / Cowan, J. / O'Connell, M. / Crabb, S.J. / Packham, G.K. / Mai, A. / Baron, R. / Ganesan, A. / Mattevi, A. 履歴 登録 2013年2月13日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2013年6月12日 Provider : repository / タイプ : Initial release改定 1.1 2013年8月28日 Group : Database references改定 1.2 2023年12月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_site Item : _citation.page_last / _database_2.pdbx_DOI ... _citation.page_last / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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