登録情報 データベース : PDB / ID : 3wzu 構造の表示 ダウンロードとリンクタイトル THE STRUCTURE OF MAP2K7 IN COMPLEX WITH 5Z-7-oxozeaenol 要素Dual specificity mitogen-activated protein kinase kinase 7 詳細 キーワード TRANSFERASE/TRANSFERASE INHIBITOR / PROTEIN KINASE / TRANSFERASE-TRANSFERASE INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
JUN kinase kinase activity / regulation of motor neuron apoptotic process / mitogen-activated protein kinase kinase / response to osmotic stress / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / positive regulation of telomere capping / Uptake and function of anthrax toxins / MAP kinase activity / cellular response to interleukin-1 ... JUN kinase kinase activity / regulation of motor neuron apoptotic process / mitogen-activated protein kinase kinase / response to osmotic stress / Fc-epsilon receptor signaling pathway / MAP kinase kinase activity / positive regulation of telomere capping / Uptake and function of anthrax toxins / MAP kinase activity / cellular response to interleukin-1 / response to tumor necrosis factor / response to UV / stress-activated MAPK cascade / positive regulation of JUN kinase activity / JNK cascade / : / positive regulation of telomere maintenance via telomerase / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / molecular function activator activity / FCERI mediated MAPK activation / positive regulation of JNK cascade / response to wounding / cellular senescence / response to heat / cellular response to lipopolysaccharide / protein phosphatase binding / protein tyrosine kinase activity / Oxidative Stress Induced Senescence / positive regulation of ERK1 and ERK2 cascade / phosphorylation / protein serine kinase activity / apoptotic process / protein kinase binding / positive regulation of DNA-templated transcription / enzyme binding / magnesium ion binding / signal transduction / ATP binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain ... Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Chem-1FM / Dual specificity mitogen-activated protein kinase kinase 7 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.01 Å 詳細データ登録者 Sogabe, Y. / Hashimoto, Y. / Matsumoto, T. / Kinoshita, T. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2015タイトル : 5Z-7-Oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner.著者 : Sogabe, Y. / Matsumoto, T. / Hashimoto, T. / Kirii, Y. / Sawa, M. / Kinoshita, T. 履歴 登録 2014年10月7日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2015年1月14日 Provider : repository / タイプ : Initial release改定 1.1 2017年11月22日 Group : Refinement description / カテゴリ : software改定 1.2 2022年8月24日 Group : Database references / Derived calculationsカテゴリ : citation / database_2 ... citation / database_2 / struct_ref_seq_dif / struct_site Item : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.3 2023年11月8日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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