Entry Database : PDB / ID : 3wjj Structure visualization Downloads & linksTitle Crystal structure of IIb selective Fc variant, Fc(P238D), in complex with FcgRIIb ComponentsIg gamma-1 chain C region Low affinity immunoglobulin gamma Fc region receptor II-b DetailsKeywords IMMUNE SYSTEM / RECEPTOR COMPLEX / FC RECEPTOR / ANTIBODYFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of type I hypersensitivity / negative regulation of antibody-dependent cellular cytotoxicity / immune effector process / follicular dendritic cell activation / immune complex clearance by monocytes and macrophages / regulation of B cell antigen processing and presentation / regulation of immune complex clearance by monocytes and macrophages / regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway / positive regulation of response to endoplasmic reticulum stress / negative regulation of acute inflammatory response to antigenic stimulus ... negative regulation of type I hypersensitivity / negative regulation of antibody-dependent cellular cytotoxicity / immune effector process / follicular dendritic cell activation / immune complex clearance by monocytes and macrophages / regulation of B cell antigen processing and presentation / regulation of immune complex clearance by monocytes and macrophages / regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway / positive regulation of response to endoplasmic reticulum stress / negative regulation of acute inflammatory response to antigenic stimulus / positive regulation of humoral immune response / negative regulation of neutrophil activation / negative regulation of dendritic cell antigen processing and presentation / negative regulation of B cell receptor signaling pathway / negative regulation of humoral immune response mediated by circulating immunoglobulin / low-affinity IgG receptor activity / follicular B cell differentiation / negative regulation of cytotoxic T cell degranulation / negative regulation of immunoglobulin production / cellular response to molecule of bacterial origin / negative regulation of dendritic cell differentiation / regulation of dendritic spine maintenance / negative regulation of B cell activation / IgG receptor activity / regulation of adaptive immune response / mature B cell differentiation involved in immune response / negative regulation of macrophage activation / Fc-gamma receptor signaling pathway / negative regulation of immune response / Fc-gamma receptor I complex binding / complement-dependent cytotoxicity / regulation of signaling receptor activity / IgG immunoglobulin complex / negative regulation of phagocytosis / antibody-dependent cellular cytotoxicity / IgG binding / negative regulation of cytokine production / Classical antibody-mediated complement activation / phagocytosis, engulfment / Initial triggering of complement / negative regulation of interleukin-10 production / regulation of innate immune response / negative regulation of B cell proliferation / FCGR activation / immunoglobulin mediated immune response / Role of phospholipids in phagocytosis / phagocytosis / positive regulation of phagocytosis / immunoglobulin complex, circulating / immunoglobulin receptor binding / cerebellum development / FCGR3A-mediated IL10 synthesis / receptor-mediated endocytosis / complement activation, classical pathway / Regulation of Complement cascade / positive regulation of JNK cascade / FCGR3A-mediated phagocytosis / antigen binding / response to bacterium / B cell receptor signaling pathway / Regulation of actin dynamics for phagocytic cup formation / defense response / cellular response to amyloid-beta / antigen processing and presentation of exogenous peptide antigen via MHC class II / positive regulation of tumor necrosis factor production / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / amyloid-beta binding / cell body / antibacterial humoral response / Interleukin-4 and Interleukin-13 signaling / adaptive immune response / dendritic spine / cell surface receptor signaling pathway / blood microparticle / inflammatory response / external side of plasma membrane / protein-containing complex binding / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function Immunoglobulin domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain ... Immunoglobulin domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.6 Å DetailsAuthors Kadono, S. / Mimoto, F. / Katada, H. / Igawa, T. / Kuramochi, T. / Muraoka, M. / Wada, Y. / Haraya, K. / Miyazaki, T. / Hattori, K. CitationJournal : Protein Eng.Des.Sel. / Year : 2013Title : Engineered antibody Fc variant with selectively enhanced Fc gamma RIIb binding over both Fc gamma RIIaR131 and Fc gamma RIIaH131.Authors : Mimoto, F. / Katada, H. / Kadono, S. / Igawa, T. / Kuramochi, T. / Muraoka, M. / Wada, Y. / Haraya, K. / Miyazaki, T. / Hattori, K. History Deposition Oct 10, 2013 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Nov 13, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Nov 26, 2014 Group : OtherRevision 1.2 Jun 20, 2018 Group : Data collection / Source and taxonomy / Category : entity_src_genItem : _entity_src_gen.host_org_common_name / _entity_src_gen.pdbx_host_org_cell_line / _entity_src_gen.pdbx_host_org_strainRevision 2.0 Jul 29, 2020 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_ref_seq_dif / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details Description : Carbohydrate remediation / Provider : repository / Type : Remediation
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