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TitleEngineered antibody Fc variant with selectively enhanced Fc gamma RIIb binding over both Fc gamma RIIaR131 and Fc gamma RIIaH131.
Journal, issue, pagesProtein Eng. Des. Sel., Vol. 26, Page 589-598, Year 2013
Publish dateOct 10, 2013 (structure data deposition date)
AuthorsMimoto, F. / Katada, H. / Kadono, S. / Igawa, T. / Kuramochi, T. / Muraoka, M. / Wada, Y. / Haraya, K. / Miyazaki, T. / Hattori, K.
External linksProtein Eng. Des. Sel. / PubMed:23744091
MethodsX-ray diffraction
Resolution2.6 - 2.86 Å
Structure data

PDB-3wjj:
Crystal structure of IIb selective Fc variant, Fc(P238D), in complex with FcgRIIb
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-3wjl:
Crystal structure of IIb selective Fc variant, Fc(V12), in complex with FcgRIIb
Method: X-RAY DIFFRACTION / Resolution: 2.86 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / RECEPTOR COMPLEX / FC RECEPTOR / ANTIBODY

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