登録情報 データベース : PDB / ID : 3vyx 構造の表示 ダウンロードとリンクタイトル Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase (DHX9) 要素ATP-dependent RNA helicase A RNA (5'-R(P*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3') 詳細キーワード HYDROLASE/RNA / protein-dsRNA complex / dsRBD fold / dsRNA binding / protein-protein interaction / HYDROLASE-RNA complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
single-stranded 3'-5' DNA helicase activity / 3'-5' DNA/RNA helicase activity / CRD-mediated mRNA stability complex / regulation of cytoplasmic translation / regulatory region RNA binding / positive regulation of RNA export from nucleus / DNA-templated viral transcription / positive regulation of viral transcription / triplex DNA binding / positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity ... single-stranded 3'-5' DNA helicase activity / 3'-5' DNA/RNA helicase activity / CRD-mediated mRNA stability complex / regulation of cytoplasmic translation / regulatory region RNA binding / positive regulation of RNA export from nucleus / DNA-templated viral transcription / positive regulation of viral transcription / triplex DNA binding / positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity / RISC complex binding / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / CRD-mediated mRNA stabilization / protein localization to cytoplasmic stress granule / G-quadruplex DNA unwinding / nucleoside triphosphate diphosphatase activity / nuclear stress granule / positive regulation of interleukin-18 production / perichromatin fibrils / DEx/H-box helicases activate type I IFN and inflammatory cytokines production / 3'-5' RNA helicase activity / alternative mRNA splicing, via spliceosome / RNA secondary structure unwinding / RISC-loading complex / miRNA-mediated post-transcriptional gene silencing / RISC complex assembly / regulation of mRNA processing / regulation of defense response to virus by host / importin-alpha family protein binding / RIP-mediated NFkB activation via ZBP1 / positive regulation of response to cytokine stimulus / siRNA binding / positive regulation of cytoplasmic translation / positive regulation of innate immune response / RISC complex / sequence-specific mRNA binding / RNA polymerase binding / DNA duplex unwinding / 3'-5' DNA helicase activity / cellular response to exogenous dsRNA / pyroptotic inflammatory response / RNA polymerase II complex binding / DNA replication origin binding / positive regulation of interferon-alpha production / mRNA transport / positive regulation of interferon-beta production / DNA helicase activity / positive regulation of DNA repair / ribonucleoside triphosphate phosphatase activity / mRNA Splicing - Major Pathway / positive regulation of DNA replication / promoter-specific chromatin binding / DNA-templated transcription termination / transcription coregulator activity / PKR-mediated signaling / chromatin DNA binding / positive regulation of inflammatory response / cytoplasmic ribonucleoprotein granule / positive regulation of interleukin-6 production / osteoblast differentiation / RNA stem-loop binding / positive regulation of tumor necrosis factor production / double-stranded RNA binding / positive regulation of fibroblast proliferation / actin cytoskeleton / rhythmic process / ribosome binding / cellular response to tumor necrosis factor / positive regulation of NF-kappaB transcription factor activity / single-stranded DNA binding / double-stranded DNA binding / protein-containing complex assembly / DNA replication / RNA polymerase II-specific DNA-binding transcription factor binding / RNA helicase activity / transcription coactivator activity / single-stranded RNA binding / nuclear body / RNA helicase / ribonucleoprotein complex / inflammatory response / RNA polymerase II cis-regulatory region sequence-specific DNA binding / innate immune response / mRNA binding / centrosome / regulation of transcription by RNA polymerase II / nucleolus / positive regulation of transcription by RNA polymerase II / ATP hydrolysis activity / protein-containing complex / DNA binding / RNA binding / nucleoplasm / ATP binding / membrane / nucleus / metal ion binding / cytosol / cytoplasm 類似検索 - 分子機能 DHX9, first double-stranded RNA binding domain / DHX9, second double-stranded RNA binding domain / DHX9, DEXH-box helicase domain / : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase-associated domain / Helicase associated domain (HA2), winged-helix / Helicase associated domain (HA2) Add an annotation ... DHX9, first double-stranded RNA binding domain / DHX9, second double-stranded RNA binding domain / DHX9, DEXH-box helicase domain / : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase-associated domain / Helicase associated domain (HA2), winged-helix / Helicase associated domain (HA2) Add an annotation / Double Stranded RNA Binding Domain - #20 / Double-stranded RNA binding motif / Double-stranded RNA binding motif / DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site / DEAH-box subfamily ATP-dependent helicases signature. / Double stranded RNA-binding domain (dsRBD) profile. / Double-stranded RNA-binding domain / Double Stranded RNA Binding Domain / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / P-loop containing nucleoside triphosphate hydrolase / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.29 Å 詳細データ登録者 Yuan, Y.A. / Fu, Q. 引用ジャーナル : Nucleic Acids Res. / 年 : 2013タイトル : Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9).著者 : Fu, Q. / Yuan, Y.A. 履歴 登録 2012年10月5日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2013年2月13日 Provider : repository / タイプ : Initial release改定 1.1 2022年8月24日 Group : Database references / カテゴリ : citation / database_2 / struct_ref_seq_difItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details 改定 1.2 2023年11月8日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model改定 1.3 2024年3月20日 Group : Source and taxonomy / Structure summary / カテゴリ : entity / pdbx_entity_src_syn / Item : _entity.details
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