登録情報 データベース : PDB / ID : 3v3v 構造の表示 ダウンロードとリンクタイトル Structural and functional analysis of quercetagetin, a natural JNK1 inhibitor 要素C-Jun-amino-terminal kinase-interacting protein 1 Mitogen-activated protein kinase 8 詳細キーワード TRANSFERASE/TRANSFERASE INHIBITOR / TRANSFERASE / PHOSPHORYLATION / TRANSFERASE-TRANSFERASE INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of cell killing / dentate gyrus mossy fiber / JUN phosphorylation / regulation of CD8-positive, alpha-beta T cell proliferation / Interleukin-38 signaling / Activation of BMF and translocation to mitochondria / basal dendrite / Activation of BIM and translocation to mitochondria / JUN kinase activity / WNT5:FZD7-mediated leishmania damping ... positive regulation of cell killing / dentate gyrus mossy fiber / JUN phosphorylation / regulation of CD8-positive, alpha-beta T cell proliferation / Interleukin-38 signaling / Activation of BMF and translocation to mitochondria / basal dendrite / Activation of BIM and translocation to mitochondria / JUN kinase activity / WNT5:FZD7-mediated leishmania damping / negative regulation of JUN kinase activity / MAP-kinase scaffold activity / negative regulation of JNK cascade / JUN kinase binding / mitogen-activated protein kinase kinase kinase binding / positive regulation of cyclase activity / histone deacetylase regulator activity / mitogen-activated protein kinase kinase binding / positive regulation of NLRP3 inflammasome complex assembly / DSCAM interactions / NRAGE signals death through JNK / Activation of the AP-1 family of transcription factors / kinesin binding / dendritic growth cone / Fc-epsilon receptor signaling pathway / regulation of JNK cascade / mitogen-activated protein kinase / regulation of macroautophagy / axonal growth cone / response to mechanical stimulus / response to UV / stress-activated MAPK cascade / protein serine/threonine kinase binding / negative regulation of intrinsic apoptotic signaling pathway / vesicle-mediated transport / JNK cascade / cellular response to cadmium ion / positive regulation of protein metabolic process / cellular response to amino acid starvation / NRIF signals cell death from the nucleus / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / negative regulation of protein binding / mitochondrial membrane / FCERI mediated MAPK activation / positive regulation of JNK cascade / peptidyl-threonine phosphorylation / regulation of circadian rhythm / histone deacetylase binding / cellular response to reactive oxygen species / cellular response to mechanical stimulus / regulation of protein localization / cellular senescence / Signaling by ALK fusions and activated point mutants / rhythmic process / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / cellular response to oxidative stress / cellular response to lipopolysaccharide / peptidyl-serine phosphorylation / protein phosphatase binding / Oxidative Stress Induced Senescence / response to oxidative stress / neuron projection / positive regulation of apoptotic process / axon / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / neuronal cell body / synapse / dendrite / positive regulation of gene expression / regulation of DNA-templated transcription / endoplasmic reticulum membrane / negative regulation of apoptotic process / protein kinase binding / perinuclear region of cytoplasm / enzyme binding / signal transduction / nucleoplasm / ATP binding / identical protein binding / membrane / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 JIP1, SH3 domain / : / Mitogen-activated protein (MAP) kinase, JNK / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / Variant SH3 domain / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. ... JIP1, SH3 domain / : / Mitogen-activated protein (MAP) kinase, JNK / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / Variant SH3 domain / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / PH-like domain superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Chem-MYU / Mitogen-activated protein kinase 8 / C-Jun-amino-terminal kinase-interacting protein 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)Mus musculus (ハツカネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.7 Å 詳細データ登録者 Baek, S. / Kang, N.J. / Popowicz, G.M. / Arciniega, M. / Jung, S.K. / Byun, S. / Song, N.R. / Heo, Y.S. / Kim, B.Y. / Lee, H.J. ...Baek, S. / Kang, N.J. / Popowicz, G.M. / Arciniega, M. / Jung, S.K. / Byun, S. / Song, N.R. / Heo, Y.S. / Kim, B.Y. / Lee, H.J. / Holak, T.A. / Augustin, M. / Bode, A.M. / Huber, R. / Dong, Z. / Lee, K.W. 引用ジャーナル : J.Mol.Biol. / 年 : 2013タイトル : Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin.著者 : Baek, S. / Kang, N.J. / Popowicz, G.M. / Arciniega, M. / Jung, S.K. / Byun, S. / Song, N.R. / Heo, Y.S. / Kim, B.Y. / Lee, H.J. / Holak, T.A. / Augustin, M. / Bode, A.M. / Huber, R. / Dong, Z. / Lee, K.W. 履歴 登録 2011年12月14日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2012年12月5日 Provider : repository / タイプ : Initial release改定 1.1 2013年1月30日 Group : Database references改定 1.2 2023年9月13日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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