- PDB-3uzy: Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in com... -
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Basic information
Entry
Database: PDB / ID: 3uzy
Title
Crystal structure of 5beta-reductase (AKR1D1) E120H mutant in complex with NADP+ and 5beta-dihydrotestosterone
Components
3-oxo-5-beta-steroid 4-dehydrogenase
Keywords
OXIDOREDUCTASE / ALDO-KETO REDUCTASE / STEROID AND BILE ACID METABOLISM / CATALYTIC TETRAD MUTANT / Tim Barrel
Function / homology
Function and homology information
Delta4-3-oxosteroid 5beta-reductase / steroid dehydrogenase activity / C21-steroid hormone metabolic process / bile acid catabolic process / Delta4-3-oxosteroid 5beta-reductase activity / ketosteroid monooxygenase activity / Synthesis of bile acids and bile salts via 24-hydroxycholesterol / bile acid biosynthetic process / aldo-keto reductase (NADPH) activity / aldose reductase (NADPH) activity ...Delta4-3-oxosteroid 5beta-reductase / steroid dehydrogenase activity / C21-steroid hormone metabolic process / bile acid catabolic process / Delta4-3-oxosteroid 5beta-reductase activity / ketosteroid monooxygenase activity / Synthesis of bile acids and bile salts via 24-hydroxycholesterol / bile acid biosynthetic process / aldo-keto reductase (NADPH) activity / aldose reductase (NADPH) activity / androgen metabolic process / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / cholesterol catabolic process / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / digestion / steroid binding / cytosol Similarity search - Function
Aldo-keto reductase family 1 member D1 / Aldo/keto reductase family putative active site signature. / Aldo/keto reductase family signature 1. / NADP-dependent oxidoreductase domain / Aldo/keto reductase family signature 2. / Aldo/keto reductase, conserved site / Aldo-keto reductase / NADP-dependent oxidoreductase domain / Aldo/keto reductase family / NADP-dependent oxidoreductase domain superfamily ...Aldo-keto reductase family 1 member D1 / Aldo/keto reductase family putative active site signature. / Aldo/keto reductase family signature 1. / NADP-dependent oxidoreductase domain / Aldo/keto reductase family signature 2. / Aldo/keto reductase, conserved site / Aldo-keto reductase / NADP-dependent oxidoreductase domain / Aldo/keto reductase family / NADP-dependent oxidoreductase domain superfamily / TIM Barrel / Alpha-Beta Barrel / Alpha Beta Similarity search - Domain/homology
5-beta-DIHYDROTESTOSTERONE / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / Aldo-keto reductase family 1 member D1 Similarity search - Component
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