- PDB-3utm: Crystal structure of a mouse Tankyrase-Axin complex -
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基本情報
登録情報
データベース: PDB / ID: 3utm
タイトル
Crystal structure of a mouse Tankyrase-Axin complex
要素
Axin-1
Tankyrase-1
キーワード
TRANSFERASE/SIGNALING PROTEIN / Tankyrase / TNKS / ankryin repeat clusters / Wnt signaling / poly-ADP-ribosylation / TRANSFERASE-SIGNALING PROTEIN complex
機能・相同性
機能・相同性情報
protein-containing complex assembly => GO:0065003 / Beta-catenin phosphorylation cascade / Disassembly of the destruction complex and recruitment of AXIN to the membrane / TCF dependent signaling in response to WNT / armadillo repeat domain binding / Degradation of AXIN / negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric / Regulation of PTEN stability and activity / : / head development ...protein-containing complex assembly => GO:0065003 / Beta-catenin phosphorylation cascade / Disassembly of the destruction complex and recruitment of AXIN to the membrane / TCF dependent signaling in response to WNT / armadillo repeat domain binding / Degradation of AXIN / negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric / Regulation of PTEN stability and activity / : / head development / : / Degradation of beta-catenin by the destruction complex / dorsal/ventral axis specification / axial mesoderm formation / genomic imprinting / cellular response to nutrient / post-anal tail morphogenesis / axial mesoderm development / Ub-specific processing proteases / beta-catenin destruction complex / positive regulation of ubiquitin-dependent protein catabolic process / dorsal/ventral pattern formation / I-SMAD binding / Wnt signalosome / regulation of canonical Wnt signaling pathway / negative regulation of protein metabolic process / nucleocytoplasmic transport / positive regulation of ubiquitin-protein transferase activity / NAD+ ADP-ribosyltransferase / protein localization to chromosome, telomeric region / negative regulation of telomere maintenance via telomere lengthening / protein auto-ADP-ribosylation / protein poly-ADP-ribosylation / negative regulation of fat cell differentiation / activation of protein kinase activity / negative regulation of Wnt signaling pathway / mitotic spindle pole / positive regulation of transforming growth factor beta receptor signaling pathway / negative regulation of transcription elongation by RNA polymerase II / SMAD binding / positive regulation of telomere capping / NAD+-protein ADP-ribosyltransferase activity / R-SMAD binding / NAD+-protein poly-ADP-ribosyltransferase activity / 転移酵素; グリコシル基を移すもの; 五炭糖残基を移すもの / lateral plasma membrane / canonical Wnt signaling pathway / positive regulation of protein kinase activity / mRNA transport / nuclear pore / signaling adaptor activity / cytoplasmic microtubule organization / positive regulation of JUN kinase activity / positive regulation of telomere maintenance via telomerase / nucleotidyltransferase activity / positive regulation of peptidyl-threonine phosphorylation / positive regulation of protein ubiquitination / cell periphery / sensory perception of sound / positive regulation of JNK cascade / regulation of protein phosphorylation / negative regulation of canonical Wnt signaling pathway / protein catabolic process / Wnt signaling pathway / beta-catenin binding / protein polyubiquitination / positive regulation of protein catabolic process / positive regulation of canonical Wnt signaling pathway / p53 binding / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein transport / positive regulation of peptidyl-serine phosphorylation / histone binding / cell cortex / cytoplasmic vesicle / nuclear membrane / in utero embryonic development / chromosome, telomeric region / molecular adaptor activity / postsynaptic density / nuclear body / positive regulation of protein phosphorylation / protein domain specific binding / cell division / Golgi membrane / negative regulation of gene expression / signaling receptor binding / centrosome / ubiquitin protein ligase binding / apoptotic process / protein kinase binding / perinuclear region of cytoplasm / positive regulation of DNA-templated transcription / Golgi apparatus / enzyme binding / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / zinc ion binding / identical protein binding 類似検索 - 分子機能
解像度: 2→30 Å / Cor.coef. Fo:Fc: 0.963 / Cor.coef. Fo:Fc free: 0.948 / Occupancy max: 1 / Occupancy min: 1 / SU B: 7.628 / SU ML: 0.117 / 交差検証法: THROUGHOUT / ESU R: 0.142 / ESU R Free: 0.141 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT
Rfactor
反射数
%反射
Selection details
Rfree
0.23847
3293
5 %
RANDOM
Rwork
0.20709
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-
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obs
0.2087
62479
99.85 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.2 Å / 溶媒モデル: MASK