- PDB-3us9: Crystal Structure of the NCX1 Intracellular Tandem Calcium Bindin... -
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Basic information
Entry
Database: PDB / ID: 3us9
Title
Crystal Structure of the NCX1 Intracellular Tandem Calcium Binding Domains(CBD12)
Components
Sodium/calcium exchanger 1
Keywords
METAL BINDING PROTEIN / beta-sandwich / Calcium binding protein / intracellular
Function / homology
Function and homology information
Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration / Ion homeostasis / calcium:sodium antiporter activity / cell communication / sodium ion import across plasma membrane / intracellular sodium ion homeostasis / ankyrin binding / calcium ion import across plasma membrane ...Reduction of cytosolic Ca++ levels / Sodium/Calcium exchangers / calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration / Ion homeostasis / calcium:sodium antiporter activity / cell communication / sodium ion import across plasma membrane / intracellular sodium ion homeostasis / ankyrin binding / calcium ion import across plasma membrane / positive regulation of the force of heart contraction / sodium ion transmembrane transport / positive regulation of bone mineralization / response to muscle stretch / calcium ion transmembrane transport / sarcolemma / postsynapse / calmodulin binding / axon / calcium ion binding / nucleoplasm / plasma membrane Similarity search - Function
Sodium/calcium exchanger, isoform 1 / CalX-beta domain / : / Sodium/calcium exchanger protein / Sodium/calcium exchanger domain, C-terminal extension / C-terminal extension of sodium/calcium exchanger domain / Na-Ca exchanger/integrin-beta4 / Calx-beta domain / Domains in Na-Ca exchangers and integrin-beta4 / NCX, central ion-binding domain superfamily ...Sodium/calcium exchanger, isoform 1 / CalX-beta domain / : / Sodium/calcium exchanger protein / Sodium/calcium exchanger domain, C-terminal extension / C-terminal extension of sodium/calcium exchanger domain / Na-Ca exchanger/integrin-beta4 / Calx-beta domain / Domains in Na-Ca exchangers and integrin-beta4 / NCX, central ion-binding domain superfamily / Sodium/calcium exchanger membrane region / Sodium/calcium exchanger protein / CalX-like domain superfamily / DnaJ domain / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homology
Mass: 18.015 Da / Num. of mol.: 12 / Source method: isolated from a natural source / Formula: H2O
Sequence details
P23685 IS THE CARDIAC SPLICE VARIANT, INCLUDING EXONS ACDEF. THE SEQUENCE OF THIS PROTEIN IS ...P23685 IS THE CARDIAC SPLICE VARIANT, INCLUDING EXONS ACDEF. THE SEQUENCE OF THIS PROTEIN IS DERIVED FROM THE BRAIN SPLICE VARIANT, INCLUDING EXONS AD. THE RESIDUES 636-642 IN P23685 CORRESPOND TO EXON C, THE RESIDUES 649-676 IN P23685 CORRESPOND TO EXONS EF.
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 3.72 Å3/Da / Density % sol: 66.91 %
Crystal grow
Temperature: 292 K / Method: vapor diffusion, sitting drop / pH: 7.2 Details: 7% PEG 8000, 0.2M Amonium Sulphate, 10% Sucrose, pH 7.2, VAPOR DIFFUSION, SITTING DROP, temperature 292K
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