登録情報 データベース : PDB / ID : 3tsz 構造の表示 ダウンロードとリンクタイトル crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer peptide from human JAM-A cytoplasmic tail 要素Junctional adhesion molecule A Tight junction protein ZO-1 詳細キーワード CELL ADHESION / PDZ3-SH3-GUK / scaffolding / JAM / tight junction機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of establishment of endothelial barrier / positive regulation of blood-brain barrier permeability / adherens junction maintenance / memory T cell extravasation / RUNX1 regulates expression of components of tight junctions / positive regulation of cell-cell adhesion mediated by cadherin / ameloblast differentiation / Tight junction interactions / SARS-CoV-2 targets PDZ proteins in cell-cell junction / protein localization to cell-cell junction ... positive regulation of establishment of endothelial barrier / positive regulation of blood-brain barrier permeability / adherens junction maintenance / memory T cell extravasation / RUNX1 regulates expression of components of tight junctions / positive regulation of cell-cell adhesion mediated by cadherin / ameloblast differentiation / Tight junction interactions / SARS-CoV-2 targets PDZ proteins in cell-cell junction / protein localization to cell-cell junction / regulation of cell junction assembly / establishment of endothelial intestinal barrier / regulation of membrane permeability / Regulation of gap junction activity / protein localization to bicellular tight junction / gap junction / protein localization to adherens junction / Apoptotic cleavage of cell adhesion proteins / actomyosin structure organization / cell-cell junction organization / positive regulation of platelet aggregation / cell-cell junction assembly / Signaling by Hippo / intestinal absorption / tight junction / negative regulation of stress fiber assembly / podosome / regulation of bicellular tight junction assembly / leukocyte cell-cell adhesion / apical junction complex / maintenance of blood-brain barrier / positive regulation of Rho protein signal transduction / regulation of cytoskeleton organization / positive regulation of sprouting angiogenesis / bicellular tight junction / Integrin cell surface interactions / cell adhesion molecule binding / regulation of cytokine production / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / cell projection / protein localization to plasma membrane / Cell surface interactions at the vascular wall / PDZ domain binding / adherens junction / regulation of actin cytoskeleton organization / cell-cell adhesion / cellular response to mechanical stimulus / integrin binding / cell junction / apical part of cell / cell-cell junction / regulation of cell shape / virus receptor activity / actin cytoskeleton organization / basolateral plasma membrane / calmodulin binding / positive regulation of cell migration / cadherin binding / inflammatory response / positive regulation of cell population proliferation / negative regulation of apoptotic process / protein homodimerization activity / protein-containing complex / extracellular exosome / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 Junctional adhesion molecule A / Tight junction protein ZO-1 / ZO-1, SH3 domain / Tight junction protein ZO / Domain present in ZO-1 and Unc5-like netrin receptors / ZU5 domain / ZU5 domain / ZU5 domain profile. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain ... Junctional adhesion molecule A / Tight junction protein ZO-1 / ZO-1, SH3 domain / Tight junction protein ZO / Domain present in ZO-1 and Unc5-like netrin receptors / ZU5 domain / ZU5 domain / ZU5 domain profile. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Variant SH3 domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / SH3 Domains / PDZ domain / Pdz3 Domain / Immunoglobulin domain / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / PDZ domain / PDZ superfamily / Immunoglobulin V-Type / Immunoglobulin V-set domain / SH3 type barrels. / Immunoglobulin V-set domain / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Immunoglobulin subtype / Immunoglobulin / Roll / P-loop containing nucleotide triphosphate hydrolases / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性 Tight junction protein 1 / Junctional adhesion molecule A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.502 Å 詳細データ登録者 Nomme, J. / Lavie, A. 引用ジャーナル : J.Biol.Chem. / 年 : 2011タイトル : The Src Homology 3 Domain Is Required for Junctional Adhesion Molecule Binding to the Third PDZ Domain of the Scaffolding Protein ZO-1.著者 : Nomme, J. / Fanning, A.S. / Caffrey, M. / Lye, M.F. / Anderson, J.M. / Lavie, A. 履歴 登録 2011年9月13日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2011年10月12日 Provider : repository / タイプ : Initial release改定 1.1 2011年11月16日 Group : Database references改定 1.2 2011年12月28日 Group : Database references改定 1.3 2023年9月13日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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