登録情報 | データベース: PDB / ID: 3so6 |
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タイトル | Crystal structure of the LDL receptor tail in complex with autosomal recessive hypercholesterolemia PTB domain |
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要素 | - LDL receptor adaptor protein
- Low-density lipoprotein receptor
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キーワード | PROTEIN BINDING/PROTEIN TRANSPORT / PTB / endocytic adaptor / receptor / ldl / ldlr / autosomal recessive hypercholesterolemia / ARH / cholesterol / PROTEIN BINDING-PROTEIN TRANSPORT complex |
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機能・相同性 | 機能・相同性情報
Chylomicron clearance / AP-1 adaptor complex binding / regulation of phosphatidylcholine catabolic process / plasma lipoprotein particle clearance / positive regulation of lysosomal protein catabolic process / very-low-density lipoprotein particle receptor activity / positive regulation of receptor-mediated endocytosis involved in cholesterol transport / negative regulation of astrocyte activation / neurofilament / positive regulation of low-density lipoprotein particle clearance ...Chylomicron clearance / AP-1 adaptor complex binding / regulation of phosphatidylcholine catabolic process / plasma lipoprotein particle clearance / positive regulation of lysosomal protein catabolic process / very-low-density lipoprotein particle receptor activity / positive regulation of receptor-mediated endocytosis involved in cholesterol transport / negative regulation of astrocyte activation / neurofilament / positive regulation of low-density lipoprotein particle clearance / LDL clearance / receptor-mediated endocytosis involved in cholesterol transport / negative regulation of microglial cell activation / PCSK9-LDLR complex / AP-2 adaptor complex binding / cholesterol import / negative regulation of receptor recycling / low-density lipoprotein particle clearance / clathrin heavy chain binding / low-density lipoprotein particle receptor activity / positive regulation of triglyceride biosynthetic process / negative regulation of low-density lipoprotein particle clearance / intestinal cholesterol absorption / low-density lipoprotein particle binding / Chylomicron clearance / response to caloric restriction / amyloid-beta clearance by cellular catabolic process / Cargo recognition for clathrin-mediated endocytosis / LDL clearance / Clathrin-mediated endocytosis / clathrin adaptor activity / regulation of protein binding / regulation of protein metabolic process / high-density lipoprotein particle clearance / lipoprotein catabolic process / phospholipid transport / low-density lipoprotein particle / cholesterol transport / endolysosome membrane / negative regulation of amyloid fibril formation / amyloid precursor protein metabolic process / negative regulation of protein metabolic process / artery morphogenesis / cellular response to fatty acid / regulation of cholesterol metabolic process / low-density lipoprotein particle receptor binding / clathrin binding / amyloid-beta clearance / sorting endosome / cellular response to cytokine stimulus / lipoprotein particle binding / cellular response to low-density lipoprotein particle stimulus / regulation of protein localization to plasma membrane / long-term memory / phagocytosis / signaling adaptor activity / Retinoid metabolism and transport / clathrin-coated pit / somatodendritic compartment / positive regulation of vascular associated smooth muscle cell proliferation / phosphatidylinositol-4,5-bisphosphate binding / phosphotyrosine residue binding / cholesterol metabolic process / basal plasma membrane / receptor-mediated endocytosis / cholesterol homeostasis / clathrin-coated endocytic vesicle membrane / lipid metabolic process / receptor internalization / recycling endosome / cytoplasmic side of plasma membrane / positive regulation of receptor-mediated endocytosis / positive regulation of inflammatory response / endocytosis / signaling receptor complex adaptor activity / late endosome / Cargo recognition for clathrin-mediated endocytosis / apical part of cell / Clathrin-mediated endocytosis / virus receptor activity / amyloid-beta binding / basolateral plasma membrane / protease binding / molecular adaptor activity / lysosome / early endosome / receptor complex / endosome membrane / external side of plasma membrane / axon / negative regulation of gene expression / calcium ion binding / positive regulation of gene expression / Golgi apparatus / cell surface / identical protein binding / membrane / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / PTB/PI domain / LDLR class B repeat / Low-density lipoprotein-receptor YWTD domain / Low-density lipoprotein receptor domain class A / : ...Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / Low-density lipoprotein receptor repeat class B / LDL-receptor class B (LDLRB) repeat profile. / PTB/PI domain / LDLR class B repeat / Low-density lipoprotein-receptor YWTD domain / Low-density lipoprotein receptor domain class A / : / Low-density lipoprotein (LDL) receptor class A, conserved site / LDL-receptor class A (LDLRA) domain signature. / LDL-receptor class A (LDLRA) domain profile. / Calcium-binding EGF domain / Low-density lipoprotein receptor domain class A / Low-density lipoprotein (LDL) receptor class A repeat / LDL receptor-like superfamily / Six-bladed beta-propeller, TolB-like / Coagulation Factor Xa inhibitory site / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Epidermal growth factor-like domain. / EGF-like domain profile. / Growth factor receptor cysteine-rich domain superfamily / EGF-like domain signature 2. / EGF-like domain / PH-like domain superfamily / Roll / Mainly Beta類似検索 - ドメイン・相同性 Low density lipoprotein receptor adapter protein 1 / Low-density lipoprotein receptor類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ)
Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.37 Å |
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データ登録者 | Dvir, H. / Zajonc, D.M. |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2012 タイトル: Atomic structure of the autosomal recessive hypercholesterolemia phosphotyrosine-binding domain in complex with the LDL-receptor tail. 著者: Dvir, H. / Shah, M. / Girardi, E. / Guo, L. / Farquhar, M.G. / Zajonc, D.M. |
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履歴 | 登録 | 2011年6月29日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年4月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年5月2日 | Group: Database references |
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改定 1.2 | 2012年5月16日 | Group: Database references |
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改定 1.3 | 2017年11月8日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
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改定 1.4 | 2024年2月28日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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