登録情報 | データベース: PDB / ID: 3she |
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タイトル | Novel ATP-competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series |
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要素 | MAP kinase-activated protein kinase 3 |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / Kinase domain with bound inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
calcium-dependent protein serine/threonine kinase activity / macropinocytosis / calcium/calmodulin-dependent protein kinase activity / mitogen-activated protein kinase binding / toll-like receptor signaling pathway / MAP kinase kinase activity / vascular endothelial growth factor receptor signaling pathway / p38MAPK events / response to cytokine / activated TAK1 mediates p38 MAPK activation ...calcium-dependent protein serine/threonine kinase activity / macropinocytosis / calcium/calmodulin-dependent protein kinase activity / mitogen-activated protein kinase binding / toll-like receptor signaling pathway / MAP kinase kinase activity / vascular endothelial growth factor receptor signaling pathway / p38MAPK events / response to cytokine / activated TAK1 mediates p38 MAPK activation / VEGFA-VEGFR2 Pathway / MAPK cascade / Oxidative Stress Induced Senescence / response to lipopolysaccharide / calmodulin binding / non-specific serine/threonine protein kinase / intracellular signal transduction / protein serine kinase activity / protein serine/threonine kinase activity / signal transduction / nucleoplasm / ATP binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 MAP kinase activated protein kinase, C-terminal / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site ...MAP kinase activated protein kinase, C-terminal / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-I85 / MAP kinase-activated protein kinase 3類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.25 Å |
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データ登録者 | Oubrie, A. / Kazemier, B. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2012 タイトル: Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series. 著者: Oubrie, A. / Kaptein, A. / de Zwart, E. / Hoogenboom, N. / Goorden, R. / van de Kar, B. / van Hoek, M. / de Kimpe, V. / van der Heijden, R. / Borsboom, J. / Kazemier, B. / de Roos, J. / ...著者: Oubrie, A. / Kaptein, A. / de Zwart, E. / Hoogenboom, N. / Goorden, R. / van de Kar, B. / van Hoek, M. / de Kimpe, V. / van der Heijden, R. / Borsboom, J. / Kazemier, B. / de Roos, J. / Scheffers, M. / Lommerse, J. / Schultz-Fademrecht, C. / Barf, T. |
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履歴 | 登録 | 2011年6月16日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2011年12月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年1月11日 | Group: Database references |
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改定 1.2 | 2024年2月28日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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